Trypanosoma cruzi:: TcRAB7 protein is localized at the Golgi apparatus in epimastigotes

被引：16

作者：

Araripe, JR

Silva, NLCE

Leal, ST

de Souza, W

Rondinelli, E

机构：

[1] Univ Fed Rio de Janeiro, IBCCF, Lab Metab Macromol Firmino Torres Castro, Rio de Janeiro, Brazil

[2] Univ Fed Rio de Janeiro, IBCCF, Lab Ultraestruct Celular Hertha, Rio de Janeiro, Brazil

[3] Univ Fed Rio de Janeiro, Fac Med, Dept Clin Med, Rio de Janeiro, Brazil

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 2004年 / 321卷 / 02期

关键词：

Trypanosoma cruzi; Rab7; golgi apparatus; vesicle traffic;

D O I：

10.1016/j.bbrc.2004.06.159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In mammalian cells, the Rab7 protein is a key element of late endocytic membrane traffic. Several results suggest that it is involved in the transport from early to late endosome or from late endosome to lysosome. We have previously characterized a Rab7 gene homologue (TcRAB7) in Trypanosoma cruzi. Now, using an affinity-purified antibody specific to TcRAB7 protein we have determined that it is localized at the Golgi apparatus of the parasite. Our results indicate that the T. cruzi Rab7 homologue may function in a different route than its counterparts in mammalian cells. (C) 2004 Elsevier Inc. All rights reserved.

引用

页码：397 / 402

页数：6

共 29 条

[21] The kinetoplastida endocytic apparatus. Part I: a dynamic system for nutrition and evasion of host defences [J].