Activation of neurospecific gene expression by antennapedia homeobox peptide

被引：3
作者：
Biagioni, S [1 ]
Ciuffini, L [1 ]
De Jaco, A [1 ]
Vignoli, AL [1 ]
Augusti-Tocco, G [1 ]
机构：
[1] Univ Rome La Sapienza, Dipartimento Biol Cellulare & Sviluppo, I-00185 Rome, Italy
来源：
INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2000年 / 18卷 / 01期
关键词：
antennapedia peptide; development; neurofilament; choline acetyltransferase; acetylcholinesterase;
D O I：
10.1016/S0736-5748(99)00077-5
中图分类号：
Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Antennapedia homeobox peptide has been reported to enhance neurite outgrowth and branching, Thus it is of interest to investigate whether antennapedia peptide is capable of modulating the expression of genes related to different events of neuronal development. In this paper we report the enhancement of a 68 KDa neurofilament subunit, choline acetyltransferase and acetylcholinesterase expression in spinal cord neurons, elicited by antennapedia peptide. Modulation of gene expression is different with respect to each gene product analyzed, suggesting a specific action of the peptide on diverse genes controlling different events of neuronal differentiation. (C) 2000 ISDN. Published by Elsevier Science Ltd. All rights reserved.
引用
收藏
页码：93 / 99
页数：7
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