Ingol and Ingenol Diterpenes from the Aerial Parts of Euphorbia royleana and Their Antiangiogenic Activities

被引：36

作者：

Li, Xiao-Li ^{[1
]}

Li, Yang ^{[1
,2
]}

Wang, Si-Feng ^{[3
]}

Zhao, Yan-Li ^{[1
,2
]}

Liu, Ke-Chun ^{[3
]}

Wang, Xi-Min ^{[3
]}

Yang, Yong-Ping ^{[1
,4
]}

机构：

[1] Chinese Acad Sci, Kunming Inst Bot, Lab Ethnobot, Kunming Yunnan 650204, Peoples R China

[2] Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China

[3] Shandong Acad Sci, Inst Biol, Jinan 250014, Shandong, Peoples R China

[4] Chinese Acad Sci, Kunming Inst Bot, Inst Tibetan Plateau Res Kunming, Kunming 650204, Yunnan, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2009年 / 72卷 / 06期

关键词：

LATEX; FRACTION; ESTERS; KANSUI;

D O I：

10.1021/np800816n

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Ten new ingol lathyrane-type diterpenes (1-10) and two known ingenol derivatives (11 and 12) were isolated from the aerial parts of Euphorbia royleana. The structures of 1-10 were elucidated on the basis of spectroscopic methods including 2D NMR analysis, and the structure of compound I was confirmed by single-crystal X-ray crystallography. Antiangiogenic effects of all compounds except for 5 were tested using a zebrafish model, with compounds 11 and 12 being active in this bioassay.

引用

页码：1001 / 1005

页数：5

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