Hemostatic spray powder TC-325 in the primary endoscopic treatment of peptic ulcer-related bleeding: multicenter international registry

被引：26

作者：

Hussein, Mohamed ^{[1
]}

Alzoubaidi, Durayd ^{[1
]}

Lopez, Miguel-Fraile ^{[2
]}

Weaver, Michael ^{[3
]}

Ortiz-Fernandez-Sordo, Jacobo ^{[2
]}

Bassett, Paul ^{[4
]}

Rey, Johannes W. ^{[5
]}

Hayee, Bu Hussain ^{[6
]}

Despott, Edward ^{[7
]}

Murino, Alberto ^{[7
]}

Moreea, Sulleman ^{[8
]}

Boger, Philip ^{[9
]}

Dunn, Jason ^{[10
]}

Mainie, Inder ^{[11
]}

Graham, David ^{[12
]}

Mullady, Daniel K. ^{[3
]}

Early, Dayna S. ^{[3
]}

Ragunath, Krish ^{[2
]}

Anderson, John T. ^{[13
]}

Bhandari, Pradeep ^{[14
]}

Goetz, Martin ^{[15
]}

Kiesslich, Ralf ^{[16
]}

Coron, Emmanuel ^{[17
]}

Lovat, Laurence B. ^{[1
]}

Haidry, Rehan ^{[1
,12
]}

机构：

[1] UCL, Div Surg & Intervent Sci, London, England

[2] Nottingham Univ Hosp, Nottingham, England

[3] Washington Univ, Sch Med St Louis, St Louis, MO USA

[4] Statsconsultancy Ltd, Amersham, England

[5] Klinikum Osnabruck, Dept Gastroenterol, Osnabruck, Germany

[6] Kings Coll Hosp London, Dept Gastroenterol, London, England

[7] Royal Free Hosp, Dept Gastroenterol, London, England

[8] Bradford Teaching Hosp Fdn Trust, Dept Gastroenterol, Bradford, W Yorkshire, England

[9] Univ Hosp Southampton, Dept Gastroenterol, Southampton, Hants, England

[10] Guys & St Thomas Fdn Trust Hosp, Dept Gastroenterol, London, England

[11] Belfast Hlth & Social Care Trust, Dept Gastroenterol, Belfast, Antrim, North Ireland

[12] Univ Coll London Hosp, Dept Gastroenterol, London, England

[13] Gloucestershire Hosp NHS Fdn Trust, Dept Gastroenterol, Cheltenham, Glos, England

[14] Portsmouth Hosp NHS Trust, Dept Gastroenterol, Portsmouth, Hants, England

[15] Tubingen Univ Hosp, Dept Gastroenterol, Tubingen, Germany

[16] Horst Schmidt Kliniken, Wiesbaden, Germany

[17] Ctr Hosp Univ, Dept Gastroenterol, Nantes, France

来源：

ENDOSCOPY | 2021年 / 53卷 / 01期

基金：

英国工程与自然科学研究理事会;

关键词：

UPPER GASTROINTESTINAL HEMORRHAGE; ROCKALL SCORE; MANAGEMENT; RISK; HEMOSPRAY; OUTCOMES; EXPERIENCE; THERAPY; SYSTEMS; SAFETY;

D O I：

10.1055/a-1186-5360

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Background Upper gastrointestinal bleeding (UGIB) is a leading cause of morbidity and is associated with a 2%-17% mortality rate in the UK and USA. Bleeding peptic ulcers account for 50% of UGIB cases. Endoscopic intervention in a timely manner can improve outcomes. Hemostatic spray is an endoscopic hemostatic powder for GI bleeding. This multicenter registry was created to collect data prospectively on the immediate endoscopic hemostasis of GI bleeding in patients with peptic ulcer disease when hemostatic spray is applied as endoscopic monotherapy, dual therapy, or rescue therapy. Methods Data were collected prospectively (January 2016 - March 2019) from 14 centers in the UK, France, Germany, and the USA. The application of hemostatic spray was decided upon at the endoscopist's discretion. Results 202 patients with UGIB secondary to peptic ulcers were recruited. Immediate hemostasis was achieved in 178/202 patients (88%), 26/154 (17 %) experienced rebleeding, 21/175 (12%) died within 7 days, and 38/175 (22%) died within 30 days (all-cause mortality). Combination therapy of hemostatic spray with other endoscopic modalities had an associated lower 30-day mortality (16%, P<0.05) compared with monotherapy or rescue therapy. There were high immediate hemostasis rates across all peptic ulcer disease Forrest classifications. Conclusions This is the largest case series of outcomes of peptic ulcer bleeding treated with hemostatic spray, with high immediate hemostasis rates for bleeding peptic ulcers.

引用

页码：36 / 43

页数：8

共 30 条

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