Strategy to Construct 1,2,3-Triazoles by K2CO3-Mediated [4+1] Annulation Reactions of N-Acetyl Hydrazones with Bifunctional Amino Reagents

被引：9

作者：

Zhang, Xiaoke ^{[1
,2
,4
]}

Pan, Yang ^{[1
,4
]}

Wang, Haibo ^{[1
,3
,4
]}

Liang, Chong ^{[1
]}

Ma, Xiaofeng ^{[1
]}

Jiao, Wei ^{[1
]}

Shao, Huawu ^{[1
]}

机构：

[1] Chinese Acad Sci, Nat Prod Res Ctr, Chengdu Inst Biol, Chengdu, Peoples R China

[2] Zunyi Med Univ, Zunyi, Guizhou, Peoples R China

[3] Zhejiang Hongyuan Pharmaceut Co Ltd, Chem & APIs Ind Zone, Taizhou, Zhejiang, Peoples R China

[4] Univ Chinese Acad Sci, Beijing, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2021年 / 363卷 / 02期

基金：

美国国家科学基金会;

关键词：

1,2-diaza-1,3-dienes; N-acetyl hydrazones; annulation; 1,2,3-triazoles; N1; synthon; CATALYTIC ASYMMETRIC-SYNTHESIS; AZIDE-ALKYNE CYCLOADDITION; SITU-GENERATED AZOALKENES; DIELS-ALDER REACTION; DIRECT ACCESS; METAL-FREE; REGIOSELECTIVE SYNTHESIS; TOSYLHYDRAZONES; TRIAZOLES; OLEFINS;

D O I：

10.1002/adsc.202001375

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

K2CO3-mediated [4+1] annulation reactions of N-acetyl hydrazones with bifunctional amino reagents are described, which provide an environmental-friendly strategy to construct 1,2,3-triazoles that does not employ metals, azides, organocatalysis, or oxidants. A series of substituted 1,2,3-triazole derivatives was prepared with good yields.

引用

页码：459 / 463

页数：5

共 17 条

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[2] [4+1] Annulation of in situ generated azoalkenes with amines: A powerful approach to access 1-substituted 1,2,3-triazoles
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[3] Base-mediated ketenimine formation from N-sulfonylthioimidates for the synthesis of 5-amino-1-vinyl/aryl-1,2,3-triazoles
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[6] N1-, N2-, and N3-Methyl-4-nitro-1,2,3-triazoles and Metal Complexes Based on Them
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[9] Chemoselective Aza-[4+3]-annulation of N-Perfluoroalkyl-1,2,3-triazoles with 1,3-Dienes: Access to N-Perfluoroalkyl-Substituted Azepines
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[10] Metal-Free Cascade [4+1] Cyclization Access to 4-Aryl-NH-1,2,3-triazoles from N-Tosylhydrazones and Sodium Azide
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