Oxidative stress and preeclampsia: A review

被引：24

作者：

Guerby, P. ^{[1
]}

Vidal, F. ^{[1
]}

Garoby-Salom, S. ^{[2
]}

Vayssiere, C. ^{[1
,3
]}

Salvayre, R. ^{[2
]}

Parant, O. ^{[1
,3
]}

Negre-Salvayre, A. ^{[1
]}

机构：

[1] CHU Toulouse, Hop Paule de Viguier, Pole Gynecol Obstet, F-31059 Toulouse 9, France

[2] Univ Toulouse, INSERM, UMR 1048, F-31432 Toulouse 4, France

[3] Univ Toulouse 3, UMR1027, F-31073 Toulouse, France

来源：

GYNECOLOGIE OBSTETRIQUE & FERTILITE | 2015年 / 43卷 / 11期

关键词：

Preeclampsia; Oxidative stress; Pathophysiology; Antioxidant; Placenta; NITRIC-OXIDE; LIPID-PEROXIDATION; ENDOTHELIAL DYSFUNCTION; SELENIUM SUPPLEMENTATION; ANTIOXIDANT STATUS; ANGIOGENIC FACTORS; SOLUBLE ENDOGLIN; NORMAL-PREGNANCY; VITAMIN-E; WOMEN;

D O I：

10.1016/j.gyobfe.2015.09.011

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

Preeclampsia is a leading cause of pregnancy complications and affects 3-7% of pregnant women. Pathophysiology of preeclampsia is still unclear. According to the two-stage model of preeclampsia, the abnormal and hypoperfused placenta (stage 1) releases factors to the bloodstream, which are responsible for the maternal symptoms (stage 2), characterised by a systemic inflammation and endothelial dysfunction. Oxidative stress plays an important role in the pathophysiology of the preeclampsia and could be the common denominator between the two. This review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on oxidative stress. We also review the different factors that have been proposed to cause endothelial cell dysfunction in preeclampsia, and trials investigating the role of antioxidant supplementation in preeclampsia. (C) 2015 Elsevier Masson SAS. All rights reserved.

引用

页码：751 / 756

页数：6

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