Relationship between PDGFR expression and the response to pazopanib in intimal sarcoma of the pulmonary artery: A case report

被引：8

作者：

Sai, Satoshi ^{[1
]}

Imamura, Yoshinori ^{[1
]}

Kiyota, Naomi ^{[1
,2
]}

Jimbo, Naoe ^{[3
]}

Toyoda, Masanori ^{[1
]}

Funakoshi, Yohei ^{[1
]}

Chayahara, Naoko ^{[1
]}

Hyogo, Yasuko ^{[1
]}

Takenaka, Kei ^{[1
]}

Suto, Hirotaka ^{[1
]}

Minami, Hironobu ^{[1
,2
]}

机构：

[1] Kobe Univ Hosp & Grad Sch Med, Dept Med Oncol Hematol, Kobe, Hyogo 6500017, Japan

[2] Kobe Univ Hosp, Canc Ctr, Kobe, Hyogo 6500017, Japan

[3] Kobe Univ Hosp & Grad Sch Med, Dept Diagnost Pathol, Kobe, Hyogo 6500017, Japan

来源：

MOLECULAR AND CLINICAL ONCOLOGY | 2021年 / 14卷 / 01期

关键词：

case reports; intimal sarcoma; pazopanib; platelet-derived growth factor receptor; pulmonary artery; vascular endothelial growth factor receptor; GROWTH-FACTOR RECEPTOR; SOFT-TISSUE SARCOMA; OVEREXPRESSION; TARGETS;

D O I：

10.3892/mco.2020.2168

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Intimal sarcoma of the pulmonary artery (PAIS) is a rare disease with a poor prognosis. Pazopanib, which has been indicated in metastatic non-adipocytic soft-tissue sarcomas and is expected to be active in PAIS, is a multi-kinase inhibitor that targets the tyrosine kinase activity of vascular endothelial growth factor receptor (VEGFR), platelet-derived growth factor receptor (PDGFR) and stem cell factor receptor. The present study reports findings related to two cases of PAIS with PDGF and VEGF expression following treatment with pazopanib. A case with a moderate to strong expression of PDGFR-alpha and -beta presented a long-term stable disease when treated with pazopanib (progression-free survival, 5.8 months). In a second case with a weak expression of PDGFR-alpha and -beta, the disease progressed rapidly on pazopanib (progression-free survival, 1.1 months). VEGFR-2 was not expressed in the tumors of both cases. The level of PDGFR expression in the tumor tissue may therefore be predictive of pazopanib efficacy.

引用

页码：1 / 4

页数：4

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