Immunological targeting of cytomegalovirus for glioblastoma therapy

被引：21

作者：

Nair, Smita K. ^{[1
]}

Sampson, John H. ^{[1
]}

Mitchell, Duane A. ^{[2
]}

机构：

[1] Duke Univ, Med Ctr, Duke Canc Inst, Dept Surg, Durham, NC 27708 USA

[2] Univ Florida, Preston A Wells Jr Ctr Brain Tumor Therapy, Dept Neurosurg, Gainesville, FL USA

来源：

ONCOIMMUNOLOGY | 2014年 / 3卷 / 06期

关键词：

cytomegalovirus; immunotherapy; RNA-transfected dendritic cells; glioblastoma; T-CELLS; TUMORS;

D O I：

10.4161/onci.29289

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Human cytomegalovirus (CMV) is purportedly present in glioblastoma (GBM) while absent from the normal brain, making CMV antigens potentially ideal immunological anti-GBM targets. We recently demonstrated that patient-derived CMV pp65-specific T cells are capable of recognizing and killing autologous GBM tumor cells. This data supports CMV antigen-directed immunotherapies against GBM.

引用

页数：3

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