IL-27, a heterodimeric cytokine composed of EB13 and p28 protein, induces proliferation of naive CD4+ T cells

被引：1176

作者：

Pflanz, S ^{[1
]}

Timans, JC ^{[1
]}

Cheung, J ^{[1
]}

Rosales, R ^{[1
]}

Kanzler, H ^{[1
]}

Gilbert, J ^{[1
]}

Hibbert, L ^{[1
]}

Churakova, T ^{[1
]}

Travis, M ^{[1
]}

Vaisberg, E ^{[1
]}

Blumenschein, WM ^{[1
]}

Mattson, JD ^{[1
]}

Wagner, JL ^{[1
]}

To, W ^{[1
]}

Zurawski, S ^{[1
]}

McClanahan, TK ^{[1
]}

Gorman, DM ^{[1
]}

Bazan, JF ^{[1
]}

Malefyt, RD ^{[1
]}

Rennick, D ^{[1
]}

Kastelein, RA ^{[1
]}

机构：

[1] DNAX Res Inst Mol & Cellular Biol Inc, Palo Alto, CA 94304 USA

来源：

IMMUNITY | 2002年 / 16卷 / 06期

关键词：

D O I：

10.1016/S1074-7613(02)00324-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

An efficient Th1-driven adaptive immune response requires activation of the T cell receptor and secretion of the T cell stimulatory cytokine IL-12 by activated antigen-presenting cells. IL-12 triggers Th1 polarization of naive CD4(+) T cells and secretion of IFN-gamma. We describe a new heterodimeric cytokine termed IL-27 that consists of EBI3, an IL-12p40-related protein, and p28, a newly discovered IL-12p35-related polypeptide. IL-27 is an early product of activated antigen-presenting cells and drives rapid clonal expansion of naive but not memory CD4+ T cells. It also strongly synergizes with IL-12 to trigger IFN-gamma production of naive CD4(+) T cells. IL-27 mediates its biologic effects through the orphan cytokine receptor WSX-1/TCCR.

引用

页码：779 / 790

页数：12

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