A green and efficient protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives via a one-pot, four component reaction by grinding method

被引：45

作者：

Ambethkar, Sethurajan ^{[1
]}

Padmini, Vediappen ^{[1
]}

Bhuvanesh, Nattamai ^{[2
]}

机构：

[1] Madurai Kamaraj Univ, Sch Chem, Dept Organ Chem, Madurai 625021, Tamil Nadu, India

[2] Texas A&M Univ, Dept Chem, Xray Diffract Lab, College Stn, TX 77842 USA

来源：

JOURNAL OF ADVANCED RESEARCH | 2015年 / 6卷 / 06期

关键词：

Pyranopyrazole; Multicomponent; Grinding; Antioxidant; Antimicrobial; MULTICOMPONENT SYNTHESIS; L-PROLINE; BIOLOGICAL EVALUATION; AQUEOUS-MEDIUM; IN-VITRO; CATALYST; PYRANOPYRAZOLES; 4-COMPONENT; WATER; AGENTS;

D O I：

10.1016/j.jare.2014.11.011

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

An efficient grinding protocol for the synthesis of dihydropyrano[2,3-c]pyrazole derivatives from acetylene ester, hydrazine hydrate, aryl aldehydes and malononitrile under solvent free conditions has been achieved with excellent yields. The structures of the synthesized compounds were deduced by spectroscopic techniques and the compounds were further evaluated for their in vitro antioxidant and antimicrobial activities. (C) 2014 Production and hosting by Elsevier B.V. on behalf of Cairo University.

引用

页码：975 / 985

页数：11

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