Type I IFN suppresses Cxcr2 driven neutrophil recruitment into the sensory ganglia during viral infection

被引:41
|
作者
Stock, Angus T. [1 ,2 ]
Smith, Jeffrey M. [1 ]
Carbone, Francis R. [1 ]
机构
[1] Univ Melbourne, Peter Doherty Inst Infect & Immun, Dept Microbiol & Immunol, Parkville, Vic 3010, Australia
[2] Walter & Eliza Hall Inst Med Res, Parkville, Vic 3052, Australia
来源
JOURNAL OF EXPERIMENTAL MEDICINE | 2014年 / 211卷 / 05期
基金
英国医学研究理事会; 澳大利亚研究理事会;
关键词
T-CELLS; IMMUNITY; RECEPTOR; INNATE; VIRUS; ACTIVATION; MICE;
D O I
10.1084/jem.20132183
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Infection induces the expression of inflammatory chemokines that recruit immune cells to the site of inflammation. Whereas tissues such as the intestine and skin express unique chemokines during homeostasis, whether different tissues express distinct chemokine profiles during inflammation remains unclear. With this in mind, we performed a comprehensive screen of the chemokines expressed by two tissues (skin and sensory ganglia) infected with a common viral pathogen (herpes simplex virus type 1). After infection, the skin and ganglia showed marked differences in their expression of the family of Cxcr2 chemokine ligands. Specifically, Cxcl1/2/3, which in turn controlled neutrophil recruitment, was up-regulated in the skin but absent from the ganglia. Within the ganglia, Cxcl2 expression and subsequent neutrophil recruitment was inhibited by type I interferon (IFN). Using a combination of bone marrow chimeras and intracellular chemokine staining, we show that type I IFN acted by directly suppressing Cxcl2 expression by monocytes, abrogating their ability to recruit neutrophils to the ganglia. Overall, our findings describe a novel role for IFN in the direct, and selective, inhibition of Cxcr2 chemokine ligands, which results in the inhibition of neutrophil recruitment to neuronal tissue.
引用
收藏
页码:751 / 759
页数:9
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