Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir

被引：22

作者：

Tran, Tuan Hiep ^{[1
]}

Ramasamy, Thiruganesh ^{[1
]}

Poudel, Bijay Kumar ^{[1
]}

Marasini, Nirmal ^{[1
]}

Moon, Bo Kyung ^{[1
]}

Cho, Hyuk Jun ^{[1
]}

Choi, Han-Gon ^{[2
]}

Yong, Chul Soon ^{[1
]}

Kim, Jong Oh ^{[1
]}

机构：

[1] Yeungnam Univ, Coll Pharm, Gyeongbuk 712749, South Korea

[2] Hanyang Univ, Coll Pharm, Gyeonggi 426791, South Korea

来源：

MACROMOLECULAR RESEARCH | 2014年 / 22卷 / 02期

基金：

新加坡国家研究基金会;

关键词：

cross-linking; ganciclovir; gelatin microspheres; glutaraldehyde; spray-drying; IN-VITRO RELEASE; CHITOSAN MICROSPHERES; CROSS-LINKING; SWELLING BEHAVIOR; DRUG-DELIVERY; FORMULATION; NANOPARTICLES; OPTIMIZATION; EFFICACY; GENIPIN;

D O I：

10.1007/s13233-014-2018-9

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The aim of this study was to prepare ganciclovir (GCV)-loaded cross-linked gelatin microspheres by spray-drying method. The microspheres were characterized in terms of particle size, surface morphology, loading efficiency, thermal behavior, physical characteristics, swelling properties, and the release profile in vitro. The major process and formulation parameters were optimized to obtain smaller particles with high loading capacity. The physical state examination confirmed the molecular-level dispersion of drug in the polymer. The loading efficiency determined by high-performance liquid chromatography (HPLC) was around 68%. The in vitro release experiments revealed that the GCV released from the gelatin microspheres was related to the extent of swelling, which was proportional to the drug-to-polymer ratio. These results suggest that cross-linked gelatin microspheres could be a suitable drug-delivery system for GCV.

引用

页码：124 / 130

页数：7

共 50 条

[1] Preparation and characterization of spray-dried gelatin microspheres encapsulating ganciclovir
Tuan Hiep Tran
Thiruganesh Ramasamy
Bijay Kumar Poudel
Nirmal Marasini
Bo Kyung Moon
Hyuk Jun Cho
Han-Gon Choi
Chul Soon Yong
Jong Oh Kim
Macromolecular Research, 2014, 22 : 124 - 130
[2] Preparation and characterization of spray-dried mucoadhesive microspheres of aceclofenac
Nagda, Chirag
Chotai, Narendra Prabhudas
Patel, Upendra
Patel, Sandip
Soni, Tejal
Patel, Prateek
Hingorani, Lal
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2009, 35 (10) : 1155 - 1166
[3] Preparation and Characterization of Spray-Dried Mucoadhesive Microspheres of Ketorolac for Nasal Administration
Nagda, C. D.
Chotai, N. P.
Nagda, D. C.
Patel, S. B.
Patel, U. L.
CURRENT DRUG DELIVERY, 2012, 9 (02) : 205 - 218
[4] Preparation and characterization of spray-dried polymeric nanocapsules
Müller, CR
Bassani, VL
Pohlmann, AR
Michalowski, CB
Petrovick, PR
Guterres, SS
DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY, 2000, 26 (03) : 343 - 347
[5] Spray-dried chitinosans - Part I: preparation and characterization
Rege, PR
Garmise, RJ
Block, LH
INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2003, 252 (1-2) : 41 - 51
[6] Preparation and in vitro release of spray-dried chitosan microspheres for levofloxacin delivery
Cai, Jiayu
Zhang, Yin
Du, Wennan
Nan, Kaihui
JOURNAL OF CONTROLLED RELEASE, 2011, 152 : E70 - E71
[7] Preparation and characterization of spray-dried oxidized cellulose microparticles
Kumar, V
Kang, JC
Yang, TR
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2001, 6 (03) : 449 - 458
[8] SPRAY-DRIED ALBUMIN MICROSPHERES CONTAINING NICARDIPINE
CONTE, U
GIUNCHEDI, P
MAGGI, L
TORRE, ML
EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, 1994, 40 (04) : 203 - 208
[9] Spray-dried chitosan microspheres as a pDNA carrier
Oliveira, BF
Santana, MHA
Ré, MI
DRYING TECHNOLOGY, 2006, 24 (03) : 373 - 382
[10] Solvent influence on spray-dried biodegradable microspheres
Bain, DF
Munday, DL
Smith, A
JOURNAL OF MICROENCAPSULATION, 1999, 16 (04) : 453 - 474

← 1 2 3 4 5 →