Epigenetic Regulation of miRNAs in Cancer

被引：62

作者：

Fabbri, Muller ^{[1
,2
]}

Calore, Federica ^{[3
]}

Paone, Alessio ^{[3
]}

Galli, Roberta ^{[3
]}

Calin, George A. ^{[4
]}

机构：

[1] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Dept Pediat,Div Hematol Oncol, Los Angeles, CA 90027 USA

[2] Univ So Calif, Keck Sch Med, Childrens Hosp Los Angeles, Dept Mol Microbiol & Immunol, Los Angeles, CA 90027 USA

[3] Ohio State Univ, Ctr Comprehens Canc, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[4] Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA

来源：

EPIGENETIC ALTERATIONS IN ONCOGENESIS | 2013年 / 754卷

关键词：

TUMOR-SUPPRESSOR GENE; CHRONIC LYMPHOCYTIC-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; DNA METHYLATION; COLORECTAL-CANCER; MYELOID-LEUKEMIA; MICRORNA LEVELS; BREAST-CANCER; LUNG-CANCER; CELLS;

D O I：

10.1007/978-1-4419-9967-2_6

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are short noncoding RNAs with gene regulatory functions. It has been demonstrated that the genes encoding for miRNAs undergo the same regulatory epigenetic processes of protein coding genes. In turn, a specific subgroup of miRNAs, called epi-miRNAs, is able to directly target key enzymatic effectors of the epigenetic machinery (such as DNA methyltransferases, histone deacetylases, and polycomb genes), therefore indirectly affecting the expression of epigenetically regulated oncogenes and tumor suppressor genes. Also, several of the epigenetic drugs currently approved as anticancer agents affect the expression of miRNAs and this might explain part of their mechanism of action. This chapter focuses on the tight relationship between epigenetics and miRNAs and provides some insights on the translational implications of these findings, leading to the upcoming introduction of epigenetically related miRNAs in the treatment of cancer.

引用

收藏

页码：137 / 148

页数：12

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