Significant association between CYP3A5 polymorphism and blood concentration of tacrolimus in patients with connective tissue diseases

被引：4

作者：

Tanaka, Kosuke ^{[1
]}

Terao, Chikashi ^{[1
]}

Ohmura, Koichiro ^{[2
]}

Takahashi, Meiko ^{[1
]}

Nakashima, Ran ^{[2
]}

Imura, Yoshitaka ^{[2
]}

Yoshifuji, Hajime ^{[2
]}

Yukawa, Naoichiro ^{[2
]}

Usui, Takashi ^{[2
]}

Fujii, Takao ^{[2
]}

Mimori, Tsuneyo ^{[2
]}

Matsuda, Fumihiko ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Ctr Genom Med, Kyoto 6068507, Japan

[2] Kyoto Univ, Grad Sch Med, Dept Rheumatol & Clin Immunol, Kyoto 6068507, Japan

来源：

JOURNAL OF HUMAN GENETICS | 2014年 / 59卷 / 02期

关键词：

connective tissue disease; pharmacogenetics; tacrolimus; RENAL-TRANSPLANT RECIPIENTS; AMERICAN-COLLEGE; CALCINEURIN INHIBITORS; GENETIC POLYMORPHISMS; RHEUMATOID-ARTHRITIS; REVISED CRITERIA; PHARMACOKINETICS; CLASSIFICATION; ABCB1; IMMUNOASSAY;

D O I：

10.1038/jhg.2013.129

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Although the association between CYP3A5 polymorphism and blood concentration of tacrolimus (TAC) in patients with solid organ transplantation was established, whether the association is also true in patients with connective tissue disease (CTD) who usually receive small amount of TAC is uncertain. Here, we performed a quantitative linear regression analysis to address the association between CYP3A5 and blood TAC concentration in patients with CTD. A total of 72 patients with CTD were recruited in the current study and genotyped for rs776746 in CYP3A5, which showed strong association with TAC concentration in patients with solid organ transplantation. The blood trough concentration of TAC after taking 3mg per day was retrospectively obtained for each patient. As a result, allele A of rs776746 showed a significant association with a decreasing blood concentration of TAC (P = 0.0038). Those who are carrying at least one copy of the A allele displayed decreased mean concentration of TAC by 31.0% compared with subjects with GG genotype. Rs776746 is associated with concentrations of TAC in patients with CTD.

引用

页码：107 / 109

页数：3

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