Mouse Phenome Database

被引：64

作者：

Grubb, Stephen C. ^{[1
]}

Bult, Carol J. ^{[1
]}

Bogue, Molly A. ^{[1
]}

机构：

[1] Jackson Lab, Bar Harbor, ME 04609 USA

来源：

NUCLEIC ACIDS RESEARCH | 2014年 / 42卷 / D1期

基金：

美国国家卫生研究院;

关键词：

COLLABORATIVE CROSS; GENETIC-ANALYSIS; RESOURCE; PERSPECTIVES; ONTOLOGY; TRAITS; LINES;

D O I：

10.1093/nar/gkt1159

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Mouse Phenome Database (MPD; phenome.jax.org) was launched in 2001 as the data coordination center for the international Mouse Phenome Project. MPD integrates quantitative phenotype, gene expression and genotype data into a common annotated framework to facilitate query and analysis. MPD contains >3500 phenotype measurements or traits relevant to human health, including cancer, aging, cardiovascular disorders, obesity, infectious disease susceptibility, blood disorders, neurosensory disorders, drug addiction and toxicity. Since our 2012 NAR report, we have added >70 new data sets, including data from Collaborative Cross lines and Diversity Outbred mice. During this time we have completely revamped our homepage, improved search and navigational aspects of the MPD application, developed several web-enabled data analysis and visualization tools, annotated phenotype data to public ontologies, developed an ontology browser and released new single nucleotide polymorphism query functionality with much higher density coverage than before. Here, we summarize recent data acquisitions and describe our latest improvements.

引用

页码：D825 / D834

页数：10

共 42 条

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