SARS-CoV-2; from vaccine development to drug discovery and prevention guidelines

被引:11
作者
Khodavirdipour, Amir [1 ,2 ]
Keramat, Fariba [3 ]
Hashemi, Seyed Hamid [3 ]
Alikhani, Mohammad Yousef [4 ]
机构
[1] Univ Tabriz, Fac Nat Sci, Dept Biol, Tabriz, Iran
[2] St Johns Hosp, Div Human Genet, Dept Anat, Bangalore, Karnataka, India
[3] Hamadan Univ Med Sci, Fac Med, Dept Infect Dis, Hamadan, Iran
[4] Hamadan Univ Med Sci, Dept Microbiol, Hamadan, Iran
关键词
COVID-19; vaccine; drug discovery; hrsACE2; ivermectin; famotidine; PNEUMONIA;
D O I
10.3934/molsci.2020013
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
All species of coronavirus may cause infections in birds which is known to us since the 60s, but recently, from Nov 2019, the disease emerged in humans from the seafood market in Wuhan city. The previous viral outbreaks like SARS-CoV and MERS-CoV have also shown a greater mortality rate when transmitted to humans than other animals. An emerging concern in the 2019 novel coronavirus (SARS-CoV-2) is in terms of developing vaccine or discovery of new drugs to overcome the current viral pandemic. In this rapid-review, we aim to update the available data on coronavirus with the latest findings and achievements. So far, great steps have been taken such as hrsACE2 by a Swedish team from Karolinska Institute. Monash University announced the efficacy of Ivermectin to overcome COVID-19. The CRISPR/Cas13d as a new innovative therapeutics based might overcome the challenge of COVID-19. those strains of virus which lacking E protein-encoding regions are the perfect choice for vaccine development.
引用
收藏
页码:281 / 291
页数:11
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