Microglia and Neuropathic Pain

被引：24

作者：

Aldskogius, Hakan ^{[1
]}

Kozlova, Elena N. ^{[1
]}

机构：

[1] Uppsala Univ, Biomed Ctr, Dept Neurosci, Uppsala, Sweden

来源：

CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS | 2013年 / 12卷 / 06期

基金：

瑞典研究理事会;

关键词：

Nerve injury; spinal cord injury; neuropathy; cytokine; chemokine; purine receptor; plasticity; SCIATIC-NERVE INJURY; INDUCED TACTILE ALLODYNIA; DORSAL-HORN; SPINAL-CORD; CENTRAL SENSITIZATION; MECHANICAL ALLODYNIA; GLIAL ACTIVATION; MINOCYCLINE; RECEPTOR; NEURONS;

D O I：

10.2174/18715273113126660168

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Neuropathic pain is a serious consequence of injury or disease in the nervous system itself. Current treatment options for this condition are often unsatisfactory. From being originally viewed as a diseased caused by neuronal dysfunction, a growing body of evidence implicate activated microglia as a key player in the development of this pain condition. In this review, some of the evidence for this proposal is briefly discussed and placed in a translational context, pointing out the difficulties in translating commonly used animal models of neuropathic pain to the clinical condition, as well as emphasizing the broader role of activated microglia in the injured or diseased nervous system.

引用

页码：768 / 772

页数：5

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