Discrepancy between thermodynamic and kinetic stabilities of the tert-butanol hydrates and its implication for obtaining pharmaceutical powders by freeze-drying

被引：8

作者：

Ogienko, A. G. ^{[1
,2
]}

Stoporev, A. S. ^{[1
,2
,3
]}

Ogienko, A. A. ^{[1
,4
]}

Mel'gunov, M. S. ^{[2
,5
]}

Adamova, T. P. ^{[1
]}

Yunoshev, A. S. ^{[2
,6
]}

Manakov, A. Yu ^{[1
,2
]}

Boldyreva, E., V ^{[2
,5
]}

机构：

[1] Nikolaev Inst Inorgan Chem SB RAS, Novosibirsk 630090, Russia

[2] Novosibirsk State Univ, Novosibirsk 630090, Russia

[3] Gubkin Univ, Dept Phys & Colloid Chem, Moscow 119991, Russia

[4] Inst Mol & Cellular Biol SB RAS, Novosibirsk 630090, Russia

[5] Boreskov Inst Catalysis SB RAS, Novosibirsk 630090, Russia

[6] Lavrentiev Inst Hydrodynam SB RAS, Novosibirsk 630090, Russia

来源：

CHEMICAL COMMUNICATIONS | 2019年 / 55卷 / 29期

关键词：

BUTYL ALCOHOL; PROCESS PERFORMANCE; QUALITY ATTRIBUTES; COSOLVENT SYSTEMS; ICE NUCLEATION; PHASE-DIAGRAM; LYOPHILIZATION; PRESSURE; DESIGN;

D O I：

10.1039/c9cc00397e

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The tert-butanol (TBA)-water system is studied in relation to increasing the efficiency of obtaining pharmaceutical powders by freeze-drying. Trehalose was used as a model target product. We report the X-ray diffraction and thermal analysis data which add surprising new information to the phase diagram of this previously repeatedly studied system. The freezing protocol has a strong impact on the specific surface area of the trehalose freeze-dried cakes and on the primary drying time. This is related to a discrepancy between the kinetic and thermodynamic stabilities of several TBA hydrates: di-hydrate (H1), heptahydrate (H2), and decahydrate (H3).

引用

页码：4262 / 4265

页数：4

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