Regioselective Silver-Catalyzed Carbon-Phosphorus Difunctionalization of Maleimides: One-Step Construction of Phosphonylated Indolylmaleimides and Pyrrolylmaleimides

被引：21
作者：
Yang, Zhen-Hua [1 ]
Tan, Hong-Ru [1 ]
Zhu, Jia-Nan [1 ]
Zheng, Jian [1 ]
Zhao, Sheng-Yin [1 ,2 ]
机构：
[1] Donghua Univ, Dept Chem, 2999 North Renmin Rd, Shanghai 201620, Peoples R China
[2] Chinese Acad Sci, Shanghai Inst Organ Chem, State Key Lab Bioorgan & Nat Prod Chem, Shanghai 200032, Peoples R China
来源：
ADVANCED SYNTHESIS & CATALYSIS | 2018年 / 360卷 / 07期
关键词：
silver catalysis; C-P difunctionalization; maleimides; indolylmaleimides; pyrrolylmaleimides; MICHAEL ADDITION; H-PHOSPHONATES; HECK REACTION; DERIVATIVES; INDOLES; BISINDOLYLMALEIMIDES; INHIBITORS; ANNULATION; ANALOGS; ACTIVATION;
D O I：
10.1002/adsc.201701431
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
An efficient silver-catalyzed intermolecular carbon-phosphorus difunctionalization of maleimides with indoles/pyrroles and organophosphorus compounds including dialkyl phosphites and diphenylphosphine oxide was developed. A diverse range of phosphonylated indolylmaleimides and pyrrolylmaleimides were obtained in good yields and excellent regioselectivity, involving C-P and C-C bond formations. This methodology is very practical and enables a one-step construction of difunctionalized maleimides.
引用
收藏
页码：1523 / 1528
页数：6
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