Effect of geometry on drug release from 3D printed tablets

被引:504
|
作者
Goyanes, Alvaro [1 ]
Martinez, Pamela Robles [1 ]
Buanz, Asma [1 ]
Basit, Abdul W. [1 ,2 ]
Gaisford, Simon [1 ,2 ]
机构
[1] UCL, UCL Sch Pharm, London WC1N 1AX, England
[2] FabRx Ltd, Ashford TN24 0RW, Kent, England
关键词
3D printing; Controlled-release; Fused deposition modeling; PVA; paracetamol; Hot melt extrusion; MELT EXTRUSION; FABRICATION; KINETICS;
D O I
10.1016/j.ijpharm.2015.04.069
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The aim of this work was to explore the feasibility of combining hot melt extrusion (HME) with 3D printing (3DP) technology, with a view to producing different shaped tablets which would be otherwise difficult to produce using traditional methods. A filament extruder was used to obtain approx. 4% paracetamol loaded filaments of polyvinyl alcohol with characteristics suitable for use in fused-deposition modelling 3DP. Five different tablet geometries were successfully 3D-printed-cube, pyramid, cylinder, sphere and torus. The printing process did not affect the stability of the drug. Drug release from the tablets was not dependent on the surface area but instead on surface area to volume ratio, indicating the influence that geometrical shape has on drug release. An erosion-mediated process controlled drug release. This work has demonstrated the potential of 3DP to manufacture tablet shapes of different geometries, many of which would be challenging to manufacture by powder compaction. (C) 2015 Elsevier B.V. All rights reserved.
引用
收藏
页码:657 / 663
页数:7
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