Stimuli-responsive functionalized mesoporous silica nanoparticles for drug release in response to various biological stimuli

被引：79

作者：

Chen, Xin ^{[1
,2
]}

Cheng, Xiaoyu ^{[1
,2
]}

Soeriyadi, Alexander H. ^{[1
,2
]}

Sagnella, Sharon M. ^{[1
,4
]}

Lu, Xun ^{[1
,2
]}

Scott, Jason A. ^{[3
]}

Lowe, Stuart B. ^{[1
]}

Kavallaris, Maria ^{[1
,4
]}

Gooding, J. Justin ^{[1
,2
]}

机构：

[1] Univ New S Wales, Australian Ctr Nanomed, Sydney, NSW 2052, Australia

[2] Univ New S Wales, Sch Chem, Sydney, NSW 2052, Australia

[3] Univ New S Wales, Sch Chem Engn, Sydney, NSW 2052, Australia

[4] UNSW Australia, Lowy Canc Res Ctr, Childrens Canc Inst Australia, Sydney, NSW 2052, Australia

来源：

BIOMATERIALS SCIENCE | 2014年 / 2卷 / 01期

基金：

英国医学研究理事会; 澳大利亚研究理事会;

关键词：

IN-VITRO RELEASE; SOL-GEL; GUEST MOLECULES; DELIVERY-SYSTEM; L-CYSTEINE; PH; DOXORUBICIN; MCM-41; COPPER(II); MICELLES;

D O I：

10.1039/c3bm60148j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

A silica-based mesoporous nanosphere (MSN) controlled-release drug delivery system has been synthesized and characterized. The system uses L-cysteine derivatized gold nanoparticles (AuNPs), bound to the MSNs using Cu2+ as a bridging ion. The AuNPs serve as removable caps that hinder the release of drug molecules inside the amino functionalized MSN mesoporous framework. The modified MSNs themselves exhibit negligible cytotoxicity to living cells, as revealed using the 3-(4,5-dimethylthiazol-2-yl)- 2,5-diphenyltetrazolium bromide (MTT) assay. The drug delivery system requires one of two biological stimuli to trigger drug release. These stimuli are either: low pH (pH < 5); or elevated levels of adenosine triphosphate (ATP) (concentration > 4 mM). The feasibility of biologically controlled release was demonstrated through the stimuli-induced removal of the AuNP caps over the MSN releasing the anticancer drug doxorubicin. We envisage that this MSN system could play a significant role in developing new generations of controlled-release delivery vehicles.

引用

页码：121 / 130

页数：10

共 83 条

[1] Mesoporous silicate materials as substrates for molecular machines and drug delivery [J].

Angelos, Sarah ;

Liong, Monty ;

Choi, Eunshil ;

Zink, Jeffrey I. .

CHEMICAL ENGINEERING JOURNAL, 2008, 137 (01) :4-13

[2]

[Anonymous], 1989, Recommended Dietary Allowances (RDA)

[3]

Aughenbaugh W, 2001, J BIOMED MATER RES, V57, P321, DOI 10.1002/1097-4636(20011205)57:3<321::AID-JBM1174>3.0.CO

[4]

2-S

[5] Solid-state NMR study of ibuprofen confined in MCM-41 material [J].

Azais, Thierry ;

Tourne-Peteilh, Corine ;

Aussenac, Fabien ;

Baccile, Niki ;

Coelho, Cristina ;

Devoisselle, Jean-Marie ;

Babonneau, Florence .

CHEMISTRY OF MATERIALS, 2006, 18 (26) :6382-6390

[6] pH- and Photo-Switched Release of Guest Molecules from Mesoporous Silica Supports [J].

Aznar, Elena ;

Dolores Marcos, Ma ;

Martinez-Manez, Ramon ;

Sancenon, Felix ;

Soto, Juan ;

Amoros, Pedro ;

Guillem, Carmen .

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2009, 131 (19) :6833-6843

[7] CONTENTS OF ADENINE-NUCLEOTIDES, PHOSPHAGENS AND SOME GLYCOLYTIC INTERMEDIATES IN RESTING MUSCLES FROM VERTEBRATES AND INVERTEBRATES [J].

BEIS, I ;

NEWSHOLME, EA .

BIOCHEMICAL JOURNAL, 1975, 152 (01) :23-32

[8] On the hydrothermal stability of MCM-41 mesoporous silica nanoparticles and the preparation of luminescent materials [J].

Carniato, Fabio ;

Bisio, Chiara ;

Paul, Geo ;

Gatti, Giorgio ;

Bertinetti, Luca ;

Coluccia, Salvatore ;

Marchese, Leonardo .

JOURNAL OF MATERIALS CHEMISTRY, 2010, 20 (26) :5504-5509

[9] pH and Reduction Dual-Sensitive Copolymeric Micelles for Intracellular Doxorubicin Delivery [J].

Chen, Jun ;

Qiu, Xiaozhong ;

Ouyang, Jun ;

Kong, Jiming ;

Zhong, Wen ;

Xing, Malcolm M. Q. .

BIOMACROMOLECULES, 2011, 12 (10) :3601-3611

[10] Multifunctional modified silver nanoparticles as ion and pH sensors in aqueous solution [J].

Chen, Xin ;

Cheng, Xiaoyu ;

Gooding, J. Justin .

ANALYST, 2012, 137 (10) :2338-2343

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