Exploratory analysis of Janus kinase 1 (JAK1) loss-of-function (LoF) mutations in patients with DNA mismatch repair-deficient/microsatellite instability-high (dMMR/MSI-H) metastatic colorectal cancer (mCRC) treated with nivolumab plus ipilimumab in CheckMate-142

被引：5

作者：

Kopetz, Scott ^{[1
]}

Andre, Theirry ^{[2
,3
]}

Overman, Michael J. ^{[1
]}

Zagonel, Vittorina ^{[4
]}

Lonardi, Sara ^{[4
]}

Aglietta, Massimo ^{[5
]}

Gelsomino, Fabio ^{[6
]}

McDermott, Ray ^{[7
]}

Wong, Ka Yeung Mark ^{[8
]}

Hendlisz, Alain ^{[9
]}

Garcia Alfonso, Pilar ^{[10
]}

Lenz, Heinz-Josef ^{[11
]}

Walsh, Alice ^{[12
]}

Moss, Rebecca A. ^{[12
]}

Greenawalt, Danielle ^{[12
]}

Cao, Z. Alexander ^{[12
]}

机构：

[1] Univ Texas MD Anderson Canc Ctr, Houston, TX 77030 USA

[2] UPMC Paris 06, Hop St Antoine, Paris, France

[3] UPMC Paris 06, Sorbonne Univ, Paris, France

[4] Ist Oncol Veneto IOV IRCSS, Padua, Italy

[5] Univ Torino, Turin, Italy

[6] Univ Hosp Modena, Modena, Italy

[7] St Vincents Univ Hosp, Dublin, Ireland

[8] Univ Sydney, Sydney Med Sch, Sydney, NSW, Australia

[9] Inst Jules Bordet, Brussels, Belgium

[10] Hosp Gen Univ Gregorio Maranon, Madrid, Spain

[11] Univ Southern Calif, Norris Comprehens Canc Ctr, Los Angeles, CA USA

[12] Bristol Myers Squibb, Princeton, NJ USA

来源：

CANCER RESEARCH | 2018年 / 78卷 / 13期

关键词：

PD-1; BLOCKADE; RESISTANCE;

D O I：

10.1158/1538-7445.AM2018-2603

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

2603

引用

页数：3

共 3 条

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Parisi, Giulia ;

Azhdam, Ariel ;

Chmielowski, Bartosz ;

Cherry, Grace ;

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Berent-Maoz, Beata ;

Shintaku, I. Peter ;

Le, Dung T. ;

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[3] Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma [J].

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Hugo, Willy ;

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Torrejon, Davis Y. ;

Abril-Rodriguez, Gabriel ;

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Barthly, Lucas ;

Saco, Justin ;

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Mezzadra, Riccardo ;

Chmielowski, Bartosz ;

Ruchalski, Kathleen ;

Shintaku, I. Peter ;

Sanchez, Phillip J. ;

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Cherry, Grace ;

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