Inactivation of serine protease, alpha-chymotrypsin by fluorinated phenylalanine analogues

被引：41

作者：

Ohba, T ^{[1
]}

Ikeda, E ^{[1
]}

Takei, H ^{[1
]}

机构：

[1] TOKYO INST TECHNOL,INTERDISCIPLINARY GRAD SCH SCI & ENGN,MIDORI KU,YOKOHAMA,KANAGAWA 226,JAPAN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1996年 / 6卷 / 16期

关键词：

D O I：

10.1016/0960-894X(96)00342-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fluorinated phenylalanine analogues were found to be slow-binding or reversible competitive inhibitors of alpha-chymotrypsin. A series of these compounds were designed to inactivate alpha-chymotrypsin as a result of the formation of hydrogen-bonding between fluorine atom of the inhibitors and the amide protons known as oxy-anion hole in the active-site of serine and cysteine proteases. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：1875 / 1880

页数：6

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