Diversity of homology-dependent gene silencing strategies in fungi

被引:37
作者
Faugeron, G
机构
[1] Univ Paris 07, CNRS, UMR 7592, Inst Jacques Monod, F-75251 Paris 05, France
[2] Univ Paris 06, F-75251 Paris, France
关键词
D O I
10.1016/S1369-5274(00)00066-7
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The experimental introduction of DIVA in fungi has revealed a variety of gene inactivation strategies triggered in response to the presence of homologous nucleic acid sequences. These homology effects reveal distinct classes of gene inactivation resulting from hypermutation or relying on regulatory mechanisms that operate at either the transcriptional or the post-transcriptional level.
引用
收藏
页码:144 / 148
页数:5
相关论文
共 47 条
[1]   Histone H1 is dispensable for methylation-associated gene silencing in Ascobolus immersus and essential for long life span [J].
Barra, JL ;
Rhounim, L ;
Rossignol, JL ;
Faugeron, G .
MOLECULAR AND CELLULAR BIOLOGY, 2000, 20 (01) :61-69
[2]   METHYLATION INDUCED PREMEIOTICALLY IN ASCOBOLUS - COEXTENSION WITH DNA REPEAT LENGTHS AND EFFECT ON TRANSCRIPT ELONGATION [J].
BARRY, C ;
FAUGERON, G ;
ROSSIGNOL, JL .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (10) :4557-4561
[3]   RNA as a target and an initiator of post-transcriptional gene silencing in transgenic plants [J].
Baulcombe, DC .
PLANT MOLECULAR BIOLOGY, 1996, 32 (1-2) :79-88
[4]   Methylation-induced repression - Belts, braces, and chromatin [J].
Bird, AP ;
Wolffe, AP .
CELL, 1999, 99 (05) :451-454
[5]   Masc2, a C5-DNA-methyltransferase from Ascobolus immersus with similarity to methyltransferases of higher organisms [J].
Chernov, AV ;
Vollmayr, P ;
Walter, J ;
Trautner, TA .
BIOLOGICAL CHEMISTRY, 1997, 378 (12) :1467-1473
[6]   Posttranscriptional gene silencing in Neurospora by a RecQ DNA helicase [J].
Cogoni, C ;
Macino, G .
SCIENCE, 1999, 286 (5448) :2342-2344
[7]   Isolation of quelling-defective (qde) mutants impaired in posttranscriptional transgene-induced gene silencing in Neurospora crassa [J].
Cogoni, C ;
Macino, G .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (19) :10233-10238
[8]   Gene silencing in Neurospora crassa requires a protein homologous to RNA-dependent RNA polymerase [J].
Cogoni, C ;
Macino, G .
NATURE, 1999, 399 (6732) :166-169
[9]   Transgene silencing of the al-1 gene in vegetative cells of Neurospora is mediated by a cytoplasmic effector and does not depend on DNA-DNA interactions or DNA methylation [J].
Cogoni, C ;
Irelan, JT ;
Schumacher, M ;
Schmidhauser, TJ ;
Selker, EU ;
Macino, G .
EMBO JOURNAL, 1996, 15 (12) :3153-3163
[10]   Interchromosomal transfer of epigenetic states in Ascobolus: Transfer of DNA methylation is mechanistically related to homologous recombination [J].
Colot, V ;
Maloisel, L ;
Rossignol, JL .
CELL, 1996, 86 (06) :855-864