OKT3 therapy for transfusion-associated graft-versus-host disease in a neonate

被引：1

作者：

Murakami, T ^{[1
]}

Seguchi, M ^{[1
]}

Nakazawa, M ^{[1
]}

Momma, K ^{[1
]}

机构：

[1] TOKYO WOMENS MED COLL,HEART INST JAPAN,DEPT PEDIAT CARDIOL,TOKYO 162,JAPAN

来源：

ACTA PAEDIATRICA JAPONICA | 1997年 / 39卷 / 04期

关键词：

GVHD; neonate; OKT3; open heart surgery; transfusion;

D O I：

暂无

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Transfusion-associated graft-versus-host disease (TA-GVHD) is a fatal side effect of blood transfusion. The present study describes a case of TA-GVHD in a neonate treated with anti-CD3 monoclonal antibody (OKT3). The patient died of systemic bacterial infection. However, it is suggested that OKT3 suppressed the graft-versus-host reaction due to the improvement in the clinical signs and a change in the human leucocyte antigen (HLA) type on the surface of circulating lymphocytes. A relatively large dose of OKT3 together with steroid pulse therapy and cyclosporin A may be required for the control of TA-GVHD in neonates.

引用

页码：462 / 465

页数：4

共 13 条

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