Donor KIR3DL1/receptor HLA-Bw4-80I Combination Reduces Acute Leukemia Relapse after Umbilical Cord Blood Transplantation without in Vitro T-cell Depletion

被引:2
作者
Fang, Xinchen [1 ]
Zhu, Xiaoyu [2 ]
Tang, Baolin [2 ]
Song, Kaidi [2 ]
Yao, Wen [2 ]
Wan, Xiang [2 ]
Liu, Huilan [2 ]
Peng, Jun [1 ]
Sun, Zimin [2 ]
机构
[1] Shandong Univ, Qilu Hosp, Cheeloo Coll Med, Dept Hematol, 27 Shanda South Rd, Jinan 250012, Shandong, Peoples R China
[2] Univ Sci & Technol China, Dept Hematol, Affiliated Hosp 1, Hefei 230001, Anhui, Peoples R China
基金
中国国家自然科学基金;
关键词
Acute myeloid leukemia; Natural killer cells; Killer immunoglobulin-like receptors; Umbilical cord blood transplantation; Acute lymphocytic leukemia; RECEPTORS; ALLOREACTIVITY; POLYMORPHISM;
D O I
10.4084/MJHID.2021.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Background: Donor natural killer (NK) cell alloreactivity in umbilical cord bone marrow transplantation (UCBT) can lead to leukemic relapse. However, NK cell function is calibrated by interaction with human leukocyte antigens (HLAs). This study aimed to investigate graft-resistant leukemia after transplantation and compared specific genotypes of killer immunoglobulin-like receptors (KIRs) in donors and human leukocyte antigen ligands in patients. Methods: We retrospectively analyzed 232 patients with acute leukemia from a single center. Patients had undergone UCBT with myeloablative conditioning and without anti-thymocyte globulin. We identified the KIR genotypes of cord blood donors using polymerase chain reaction with sequence-specific primers. All of the donors contained KIR3DL1. Results: The patients were divided into three groups according to the HLA-B locus. The donor KIR3DL1 and recipient HLA-Bw4-80I combination was predictive of being highly educated and was associated with a lower relapse (P=0.006) and better overall survival (probability of relapse=0.13, P < 0.001) than the uneducated group. We found no significant increase in the incidence of acute or chronic graft-versus-host disease. Conclusions: Our data suggest that the donor KIR3DL1/receptor and HLA-Bw4-80I combination in UCBT results in stronger graft-versus-leukemia effects and improved outcomes in patients with acute leukemia.
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页数:6
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