Platelet Acetyl-CoA Carboxylase Phosphorylation A Risk Stratification Marker That Reveals Platelet-Lipid Interplay in Coronary Artery Disease Patients

被引：10

作者：

Kautbally, Shakeel ^{[1
]}

Lepropre, Sophie ^{[1
]}

Onselaer, Marie-Blanche ^{[1
]}

Le Rigoleur, Astrid ^{[1
]}

Ginion, Audrey ^{[1
]}

de Ravenstein, Christophe De Meester ^{[1
]}

Ambroise, Jerome ^{[2
]}

Boudjeltia, Karim Z. ^{[3
]}

Octave, Marie ^{[1
]}

Wera, Odile ^{[4
]}

Hego, Alexandre ^{[4
]}

Pincemail, Joel ^{[5
,6
]}

Cheramy-Bien, Jean-Paul ^{[5
,6
]}

Huby, Thierry ^{[7
,8
]}

Giera, Martin ^{[9
]}

Gerber, Bernhard ^{[1
,10
]}

Pouleur, Anne-Catherine ^{[1
,10
]}

Guigas, Bruno ^{[11
,12
]}

Vanoverschelde, Jean-Louis ^{[1
,10
]}

Kefer, Joelle ^{[1
,10
]}

Bertrand, Luc ^{[1
]}

Oury, Cecile ^{[4
]}

Horman, Sandrine ^{[1
]}

Beauloye, Christophe ^{[1
,10
]}

机构：

[1] Catholic Univ Louvain, Inst Rech Expt & Clin, Pole Rech Cardiovasc, Brussels, Belgium

[2] Catholic Univ Louvain, Ctr Appl Mol Technol, Inst Rech Expt & Clin, Brussels, Belgium

[3] Univ Libre Bruxelles, Ctr Hosp Univ Charleroi, ULB Unit 222, Lab Expt Med, Charleroi, Belgium

[4] Univ Liege, Dept Cardiol, Lab Thrombosis & Hemostasis, GIGA Cardiovasc Sci, Liege, Belgium

[5] Univ Hosp Liege, Surg Res Ctr, Dept Cardiovasc Surg, Liege, Belgium

[6] Univ Hosp Liege, Plateform Nutr Antioxydante & Sante, Liege, Belgium

[7] Univ Pierre & Marie Curie Paris 6, Integrat Biol Atherosclerosis Team, INSERM UMR S 1166, Paris, France

[8] Hop La Pitie Salpetriere, Inst Cardiometab & Nutr, Paris, France

[9] Leiden Univ, Ctr Prote & Metabol, Med Ctr, Leiden, Netherlands

[10] Clin Univ St Luc, Div Cardiol, Brussels, Belgium

[11] Leiden Univ, Med Ctr, Dept Parasitol, Leiden, Netherlands

[12] Leiden Univ, Med Ctr, Dept Cell & Chem Biol, Leiden, Netherlands

来源：

JACC-BASIC TO TRANSLATIONAL SCIENCE | 2019年 / 4卷 / 05期

关键词：

AMPK; acetyl-CoA carboxylase; coronary artery disease; lipidomics; platelet; LOW-DENSITY-LIPOPROTEIN; OXIDIZED LDL; ACTIVATION; KINASE; INHIBITION; PATHWAY; MICE;

D O I：

10.1016/j.jacbts.2019.04.005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Adenosine monophosphate-activated protein kinase (AMPK) acetyl-CoA carboxylase (ACC) signaling is activated in platelets by atherogenic lipids, particularly by oxidized low-density lipoproteins, through a CD36-dependent pathway. More interestingly, increased platelet AMPK-induced ACC phosphorylation is associated with the severity of coronary artery calcification as well as acute coronary events in coronary artery disease patients. Therefore, AMPK-induced ACC phosphorylation is a potential marker for risk stratification in suspected coronary artery disease patients. The inhibition of ACC resulting from its phosphorylation impacts platelet lipid content by down-regulating triglycerides, which in turn may affect platelet function. (C) 2019 The Authors. Published by Elsevier on behalf of the American College of Cardiology Foundation.

引用

页码：596 / 610

页数：15

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