Two new tanshinone derivatives from the rhizomes of Salvia miltiorrhiza and their antiviral activities

被引：11

作者：

Yin, Zhao-Kun

Feng, Zi-Ming

Jiang, Jian-Shuang

Zhang, Xu

Zhang, Pei-Cheng ^{[1
,2
]}

Yang, Ya-Nan ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, State Key Lab Bioact Subst & Funct Nat Med, Peking Union Med Coll, Beijing 100050, Peoples R China

[2] Chinese Acad Med Sci, Inst Mat Med, Beijing 100050, Peoples R China

来源：

JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH | 2020年 / 22卷 / 01期

关键词：

Labiatae; Salvia miltiorrhiza; tanshinone diterpene derivatives; antiviral activity; isolation and purification; structure elucidation;

D O I：

10.1080/10286020.2019.1645132

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Two new naturally occurring products named salviamine G (1) and 4-methyl-9-(ethoxycarbonyl)-8-naphthoic acid (2) were isolated from the rhizomes of Salvia miltiorrhiza. Their structures were elucidated using spectroscopic data (UV, IR, HRESIMS, 1D and 2D NMR). Compounds 1 and 2 were screened for their inhibitory activity against HSV-1 and influenza A (H3N2) using acyclovir (ACV, IC50 = 0.67 mu M) and oseltamivir (IC50 = 2.01 mu M) as a positive control. Compound 1 exhibited moderate inhibitory activity against HSV-1 and influenza A (H3N2) with IC50 values of 11.11 and 8.62 mu M, respectively.

引用

页码：24 / 29

页数：6

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