Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum

被引：0
|
作者：
Che, JT [1 ]
Zhang, JT [1 ]
Qu, ZW [1 ]
Wei, G [1 ]
机构：
[1] BEIJING UNION MED COLL, BEIJING 100050, PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1997年 / 18卷 / 04期
关键词：
tetrandrine; lindane; proto-oncogene proteins c-fos; intracellular fluid; calcium; Northern blotting; immunoblotting; thin layer chromatography;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS; Lindane 30 mg.kg(-1) given by intragastric gavage (ig) increased the expression of c-fos gene to 146 mm(2) in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg(-1) given by ig 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm(2), respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist - lindane.
引用
收藏
页码：371 / 373
页数：3
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