Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum

被引：0
|
作者：
Che, JT [1 ]
Zhang, JT [1 ]
Qu, ZW [1 ]
Wei, G [1 ]
机构：
[1] BEIJING UNION MED COLL, BEIJING 100050, PEOPLES R CHINA
来源：
ACTA PHARMACOLOGICA SINICA | 1997年 / 18卷 / 04期
关键词：
tetrandrine; lindane; proto-oncogene proteins c-fos; intracellular fluid; calcium; Northern blotting; immunoblotting; thin layer chromatography;
D O I：
暂无
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
AIM: To detect the effect of tetrandrine (Tet) on c-fos gene expression in cerebrum induced by lindane, a neurotoxicant which activates Ca2+ channels. METHODS: Northern and dot blotting, dual wavelength thin layer chromatography scanner, were used in this study. RESULTS; Lindane 30 mg.kg(-1) given by intragastric gavage (ig) increased the expression of c-fos gene to 146 mm(2) in rat cerebrum 1 h after treatment. Tet 1, 2, and 4 mg.kg(-1) given by ig 30 min prior to lindane reduced c-fos gene expression in a concentration-dependent manner. Expressed genes reached only 86, 40, and 39 mm(2), respectively. CONCLUSION: Tet inhibited c-fos gene expression in rat cerebrum induced by Ca2+ agonist - lindane.
引用
收藏
页码：371 / 373
页数：3
相关论文
共 50 条
  • [1] Effect of tetrandrine on proto-oncogene c-fos expression in rat cerebrum
    车建途
    张均田
    屈志炜
    卫国
    ActaPharmacologicaSinica, 1997, (04)
  • [2] Expression of c-fos proto-oncogene in apoptotic rat spermatocytes.
    Teng, CS
    MOLECULAR BIOLOGY OF THE CELL, 1998, 9 : 367A - 367A
  • [3] PROTO-ONCOGENE C-FOS INDUCTION IN RAT HIPPOCAMPUS
    KACZMAREK, L
    SIEDLECKI, JA
    DANYSZ, W
    MOLECULAR BRAIN RESEARCH, 1988, 3 (02): : 183 - 186
  • [4] EXPRESSION OF THE PROTO-ONCOGENE FOS (C-FOS) BY PREIMPLANTATION BLASTOCYSTS OF THE PIG
    WHYTE, A
    STEWART, HJ
    DEVELOPMENT, 1989, 105 (03): : 651 - &
  • [5] Expression of mRNA for the proto-oncogene c-fos in rat basophilic leukaemia cells
    Stephan, V
    Seibt, A
    Korholz, D
    Wahn, V
    CELLULAR SIGNALLING, 1997, 9 (01) : 65 - 70
  • [6] DECREASED EXPRESSION OF C-FOS PROTO-ONCOGENE IN PSORIATIC SKIN
    BASSETSEGUIN, N
    ESCOT, C
    KERAI, C
    MION, H
    GUILHOU, JJ
    JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1990, 94 (03) : 390 - 390
  • [7] Influence of the proto-oncogene c-fos cisplatin sensitivity
    Moorehead, RA
    Singh, G
    BIOCHEMICAL PHARMACOLOGY, 2000, 59 (04) : 337 - 345
  • [8] Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and estrogen receptor beta in the human testis
    Araujo, Fabiano C.
    Oliveira, Cleida A.
    Reis, Augusto B.
    Del Puerto, Helen L.
    Martins, Almir S.
    Reis, Fernando M.
    HISTOLOGY AND HISTOPATHOLOGY, 2009, 24 (12) : 1515 - 1522
  • [9] Expression of the proto-oncogene c-fos and the immunolocalization of c-fos, phosphorylated c-fos and ERbeta proteins in the human testis.
    Araujo, F. C.
    Reis, A. B.
    Oliveira, C. A.
    Reis, F. M.
    FERTILITY AND STERILITY, 2007, 88 : S384 - S384
  • [10] CHARACTERISTICS OF C-FOS PROTO-ONCOGENE EXPRESSION IN RSMT-A5 CELLS
    YEH, CK
    KOUSVELARI, E
    JOURNAL OF DENTAL RESEARCH, 1990, 69 : 122 - 122
12345