Antioxidant Potential, Subacute Toxicity, and Beneficiary Effects of Methanolic Extract of Pomelo (Citrus grandis L. Osbeck) in Long Evan Rats

被引：26

作者：

Ali, Md Yousuf ^{[1
]}

Rumpa, Nur-E Noushin ^{[1
]}

Paul, Sudip ^{[1
]}

Hossen, Md Sakib ^{[1
]}

Tanvir, E. M. ^{[1
]}

Hossan, Tareq ^{[1
]}

Saha, Moumoni ^{[1
]}

Alam, Nadia ^{[1
]}

Karim, Nurul ^{[1
]}

Khalil, Md Ibrahim ^{[1
]}

Gan, Siew Hua ^{[2
]}

机构：

[1] Jahangirnagar Univ, Dept Biochem & Mol Biol, Lab Prevent & Integrat Biomed, Dhaka 1342, Bangladesh

[2] Monash Univ Malaysia, Sch Pharm, Jalan Lagoon Selatan, Bandar Sunway 47500, Selangor Darul, Malaysia

来源：

JOURNAL OF TOXICOLOGY | 2019年 / 2019卷

关键词：

CORONARY-HEART-DISEASE; THYME THYMUS-VULGARIS; LIPOPROTEIN CHOLESTEROL; LIPID-PEROXIDATION; DIABETES-MELLITUS; LIVER; RECOMMENDATIONS; ANTIBACTERIAL; ELECTROLYTES; POLYPHENOLS;

D O I：

10.1155/2019/2529569

中图分类号：

R99 [毒物学（毒理学）];

学科分类号：

100405 ;

摘要：

The aim of this study was to investigate the antioxidant potentials, subacute toxicity, and beneficiary effects of methanolic extract of pomelo (Citrus grandis L. Osbeck) in rats. Long Evans rats were divided into four groups of eight animals each. The rats were orally treated with three doses of pomelo (250, 500, and 1000mg/kg) once daily for 21 days. Pomelo extract contained high concentrations of polyphenols, flavonoids, and ascorbic acid while exhibiting high 1,1-diphenyl-2-picrylhydrazyl radical scavenging activity and ferric reducing antioxidant power values. There was no significant change in the body weight, percentage water content, and relative organ weight at any administered doses. In addition, no significant alterations in the hematological parameters were also observed. However, rats which received 1000mg/kg dose had a significant reduction in some serum parameters, including alanine transaminase (15.29%), alkaline phosphatase (2.5%), lactate dehydrogenase (15.5%), -glutamyltransferase (20%), creatinine (14.47%), urea (18.50%), uric acid (27.14%), total cholesterol (5.78%), triglyceride (21.44%), low-density lipoprotein cholesterol (40.74%), glucose (2.48%), and all atherogenic indices including cardiac risk ratio (24.30%), Castelli's risk index-2 (45.71%), atherogenic coefficient (42%), and atherogenic index of plasma (25%) compared to control. In addition, the highest dose (1000mg/kg) caused a significant increase in iron (12.07%) and high-density lipoprotein cholesterol (8.87%) levels. Histopathological findings of the vital organs did not indicate any pathological changes indicating that pomelo is nontoxic, safe, and serves as an important source of natural antioxidants. In addition, the fruit extract has the potential to ameliorate hepato- and nephrotoxicities and cardiovascular diseases as well as iron deficiency anemia.

引用

页数：12

共 88 条

[31] Platelets in inflammation and atherogenesis [J].

Gawaz, M ;

Langer, H ;

May, AE .

JOURNAL OF CLINICAL INVESTIGATION, 2005, 115 (12) :3378-3384

[32]

Giboney PT, 2005, AM FAM PHYSICIAN, V71, P1105

[33]

Greaves P., 2011, Histopathol. Preclin. Toxic. Stud.: Interpret. Relev. Drug Saf. Eval., P1, DOI [10.1016/C2010-0-67226-9, DOI 10.1016/C2010-0-67226-9]

[34]

Hall JE, 2011, GUYTON HALL TXB MED

[35] IRON DEPLETION AND ANEMIA - PREVALENCE, CONSEQUENCES, DIAGNOSTIC AND THERAPEUTIC IMPLICATIONS IN A DEVELOPING PAKISTANI POPULATION [J].