The DISOPRED server for the prediction of protein disorder

被引:552
作者
Ward, JJ [1 ]
McGuffin, LJ [1 ]
Bryson, K [1 ]
Buxton, BF [1 ]
Jones, DT [1 ]
机构
[1] UCL, Dept Comp Sci, Bioinformat Grp, London WC1E 6BT, England
关键词
D O I
10.1093/bioinformatics/bth195
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Dynamically disordered regions appear to be relatively abundant in eukaryotic proteomes. The DISOPRED server allows users to submit a protein sequence, and returns a probability estimate of each residue in the sequence being disordered. The results are sent in both plain text and graphical formats, and the server can also supply predictions of secondary structure to provide further structural information.
引用
收藏
页码:2138 / 2139
页数:2
相关论文
共 7 条
[1]   Gapped BLAST and PSI-BLAST: a new generation of protein database search programs [J].
Altschul, SF ;
Madden, TL ;
Schaffer, AA ;
Zhang, JH ;
Zhang, Z ;
Miller, W ;
Lipman, DJ .
NUCLEIC ACIDS RESEARCH, 1997, 25 (17) :3389-3402
[2]   The protein trinity - linking function and disorder [J].
Dunker, AK ;
Obradovic, Z .
NATURE BIOTECHNOLOGY, 2001, 19 (09) :805-806
[3]   Intrinsic disorder in cell-signaling and cancer-associated proteins [J].
Iakoucheva, LM ;
Brown, CJ ;
Lawson, JD ;
Obradovic, Z ;
Dunker, AK .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 323 (03) :573-584
[4]   Prediction of disordered regions in proteins from position specific score matrices [J].
Jones, DT ;
Ward, JJ .
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2003, 53 :573-578
[5]   Protein secondary structure prediction based on position-specific scoring matrices [J].
Jones, DT .
JOURNAL OF MOLECULAR BIOLOGY, 1999, 292 (02) :195-202
[6]   The PSIPRED protein structure prediction server [J].
McGuffin, LJ ;
Bryson, K ;
Jones, DT .
BIOINFORMATICS, 2000, 16 (04) :404-405
[7]   Prediction and functional analysis of native disorder in proteins from the three kingdoms of life [J].
Ward, JJ ;
Sodhi, JS ;
McGuffin, LJ ;
Buxton, BF ;
Jones, DT .
JOURNAL OF MOLECULAR BIOLOGY, 2004, 337 (03) :635-645