Anti-N-Methyl-D-Aspartate Receptor Encephalitis in Psychiatry

被引：3
作者：
Sakamoto, Shinji [1 ]
Kawai, Hiroki [1 ]
Okahisa, Yuko [1 ]
Tsutsui, Ko [2 ]
Kanbayashi, Takashi [2 ]
Tanaka, Keiko [3 ]
Mizuki, Yutaka [1 ]
Takaki, Manabu [1 ]
Yamada, Norihito [1 ]
机构：
[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Neuropsychiat, Okayama 7008558, Japan
[2] Akita Univ, Dept Neuropsychiat, Grad Sch Med, Akita 0108543, Japan
[3] Niigata Univ, Brain Res Inst, Dept Anim Model Dev, Niigata 9518585, Japan
来源：
ACTA MEDICA OKAYAMA | 2019年 / 73卷 / 03期
关键词：
NMDAR; encephalitis; psychiatric symptom; schizophrenia; mood disorder; NMDA-RECEPTOR; AUTOIMMUNE-DISEASES; CEREBROSPINAL-FLUID; BIPOLAR DISORDER; ANTIBODIES; SCHIZOPHRENIA; GLUTAMATE; DIAGNOSIS; AUTOANTIBODIES; PREVALENCE;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis is a recently-discovered autoimmune disorder in which antibodies target NMDAR in the brain. The number of reported cases of anti-NMDAR encephalitis has increased rapidly. Anti-NMDAR encephalitis can be mistakenly diagnosed as psychiatric disorders because many patients present with prominent psychiatric symptoms and visit psychiatric institutions first. Thus, psychiatrists should cultivate a better understanding of anti-NMDAR encephalitis. In this review, we present the mechanisms, epidemiology, symptoms and clinical course, diagnostic tests, treatment and outcomes of patients with anti-NMDAR encephalitis. Furthermore, we discuss the diversity of clinical spectra of anti-NMDAR encephalitis, and demonstrate a differential diagnosis of psychiatric disease from the perspective of psychiatry.
引用
收藏
页码：189 / 195
页数：7
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