Ketamine treatment protects against oxidative damage and the immunological response induced by electroconvulsive therapy

被引：8

作者：

Goncalves, Cinara Ludvig ^{[1
]}

Abelaira, Helena Mendes ^{[2
]}

Rosa, Thayse ^{[2
]}

de Moura, Airam Barbosa ^{[2
]}

Veron, Deise Cristina ^{[2
]}

Borba, Laura Araujo ^{[2
]}

Botelho, Maria Eduarda Mendes ^{[2
]}

Goldim, Mariana Pereira ^{[3
]}

Garbossa, Leandro ^{[3
]}

Fileti, Maria Eduarda ^{[3
]}

Petronilho, Fabricia ^{[3
]}

Ignacio, Zuleide Maria ^{[2
,4
,5
]}

Quevedo, Joao ^{[2
,6
,7
,8
]}

Reus, Gislaine Zilli ^{[2
]}

机构：

[1] Univ Southern Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Expt Neurol Lab, Criciuma, SC, Brazil

[2] Univ Southern Santa Catarina, Hlth Sci Unit, Grad Program Hlth Sci, Translat Psychiat Lab, BR-88806000 Criciuma, SC, Brazil

[3] Univ South Santa Catarina, Grad Program Hlth Sci, Neurobiol Metab & Inflammatory Proc Lab, Tubarao, SC, Brazil

[4] Fed Univ South Frontier UFFS, Lab Physiol Pharmacol & Psychopathol, Campus Chapeco, Chapeco, SC, Brazil

[5] State Secretary Justice & Citizenship Santa Catar, Chapeco, SC, Brazil

[6] Univ Texas Hlth Sci Ctr Houston UTHealth, McGovern Med Sch, Ctr Excellence Mood Disorders, Dept Psychiat & Behav Sci, Houston, TX USA

[7] Univ Texas Hlth Sci Ctr Houston UTHealth, McGovern Med Sch, Translat Psychiat Program, Dept Psychiat & Behav Sci, Houston, TX USA

[8] Univ Texas Hlth Sci Ctr Houston UTHealth, Grad Sch Biomed Sci, Neurosci Grad Program, Houston, TX USA

来源：

PHARMACOLOGICAL REPORTS | 2021年 / 73卷 / 02期

关键词：

Electroconvulsive therapy; Antidepressant; Ketamine; Oxidative stress; Neuroinflammation; Major depressive disorder; MAJOR DEPRESSION; LIPID-PEROXIDATION; RAT-BRAIN; IMMUNE-RESPONSE; NITRIC-OXIDE; STRESS; INFLAMMATION; HIPPOCAMPUS; ANESTHESIA; DISORDER;

D O I：

10.1007/s43440-020-00200-4

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Background Electroconvulsive therapy (ECT) is often recommended for major depressive disorder (MDD) for those who do not respond to the first and second antidepressant trials. A combination of two therapies could improve antidepressant efficacy. Thus, this study aimed to investigate the synergistic effects of ECT combined to antidepressants with a different mechanism of action. Methods Rats were treated once a day, for five days with ketamine (5 mg/kg), fluoxetine (1 mg/kg), and bupropion (4 mg/kg) alone or in combination with ECT (1 mA; 100 V). After, oxidative damage and antioxidant capacity were assessed in the prefrontal cortex (PFC) and hippocampus, and pro-inflammatory cytokines levels were evaluated in the serum. Results ECT alone increased lipid peroxidation in the PFC and hippocampus. In the PFC of rats treated with ECT in combination with fluoxetine and bupropion, and in the hippocampus of rats treated with ECT combined with ketamine and bupropion there was a reduction in the lipid peroxidation. The nitrite/nitrate was increased by ECT alone but reverted by combination with ketamine in the hippocampus. Superoxide dismutase (SOD) was increased by ECT and maintained by fluoxetine and bupropion in the PFC. ECT alone increased interleukin-1 beta (IL-1 beta) and the administration of ketamine was able to revert this increase showing a neuroprotective effect of this drug when in combination with ECT. Conclusion The treatment with ECT leads to an increase in oxidative damage and alters the immunological system. The combination with ketamine was able to protect against oxidative damage and the immunological response induced by ECT.

引用

页码：525 / 535

页数：11

共 66 条

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