Long non-coding and coding RNA profiling using strand-specific RNA-seq in human hypertrophic cardiomyopathy

被引：46
|
作者：
Liu, Xuanyu [1 ,2 ]
Ma, Yi [1 ,2 ]
Yin, Kunlun [1 ,2 ]
Li, Wenke [1 ,2 ]
Chen, Wen [1 ,2 ]
Zhang, Yujing [1 ,2 ]
Zhu, Changsheng [2 ,3 ]
Li, Tianjiao [1 ,2 ]
Han, Bianmei [1 ,2 ]
Liu, Xuewen [1 ,2 ]
Wang, Shuiyun [2 ,3 ]
Zhou, Zhou [1 ,2 ]
机构：
[1] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Beijing Key Lab Mol Diagnost Cardiovasc Dis, Ctr Lab Med,Fuwai Hosp,State Key Lab Cardiovasc D, Beijing 100037, Peoples R China
[2] Peking Union Med Coll, Beijing 100037, Peoples R China
[3] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Dept Cardiovasc Surg,Fuwai Hosp, Beijing 100037, Peoples R China
来源：
SCIENTIFIC DATA | 2019年 / 6卷 / 1期
基金：
中国国家自然科学基金;
关键词：
TRANSCRIPTOME;
D O I：
10.1038/s41597-019-0094-6
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Hypertrophic cardiomyopathy (HCM) represents one of the most common heritable heart diseases. However, the signalling pathways and regulatory networks underlying the pathogenesis of HCM remain largely unknown. Here, we present a strand-specific RNA-seq dataset for both coding and lncRNA profiling in myocardial tissues from 28 HCM patients and 9 healthy donors. This dataset constitutes a valuable resource for the community to examine the dysregulated coding and lncRNA genes in HCM versus normal conditions.
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页数：7
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