Long non-coding and coding RNA profiling using strand-specific RNA-seq in human hypertrophic cardiomyopathy

被引：46

作者：

Liu, Xuanyu ^{[1
,2
]}

Ma, Yi ^{[1
,2
]}

Yin, Kunlun ^{[1
,2
]}

Li, Wenke ^{[1
,2
]}

Chen, Wen ^{[1
,2
]}

Zhang, Yujing ^{[1
,2
]}

Zhu, Changsheng ^{[2
,3
]}

Li, Tianjiao ^{[1
,2
]}

Han, Bianmei ^{[1
,2
]}

Liu, Xuewen ^{[1
,2
]}

Wang, Shuiyun ^{[2
,3
]}

Zhou, Zhou ^{[1
,2
]}

机构：

[1] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, Beijing Key Lab Mol Diagnost Cardiovasc Dis, Ctr Lab Med,Fuwai Hosp,State Key Lab Cardiovasc D, Beijing 100037, Peoples R China

[2] Peking Union Med Coll, Beijing 100037, Peoples R China

[3] Chinese Acad Med Sci, Natl Ctr Cardiovasc Dis, State Key Lab Cardiovasc Dis, Dept Cardiovasc Surg,Fuwai Hosp, Beijing 100037, Peoples R China

来源：

SCIENTIFIC DATA | 2019年 / 6卷 / 1期

基金：

中国国家自然科学基金;

关键词：

TRANSCRIPTOME;

D O I：

10.1038/s41597-019-0094-6

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Hypertrophic cardiomyopathy (HCM) represents one of the most common heritable heart diseases. However, the signalling pathways and regulatory networks underlying the pathogenesis of HCM remain largely unknown. Here, we present a strand-specific RNA-seq dataset for both coding and lncRNA profiling in myocardial tissues from 28 HCM patients and 9 healthy donors. This dataset constitutes a valuable resource for the community to examine the dysregulated coding and lncRNA genes in HCM versus normal conditions.

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页数：7

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