Redistricting the retroviral restriction factors

被引：5

作者：

Greene, WC ^{[1
]}

机构：

[1] Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA

[2] Univ Calif San Francisco, San Francisco, CA 94141 USA

来源：

NATURE MEDICINE | 2004年 / 10卷 / 08期

关键词：

D O I：

10.1038/nm0804-778

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The cytoplasmic protein TRIM5alpha blocks the growth of HIV in rhesus monkey cells. Three studies now show that TRIM5alpha is an even more broadly active inhibitor. It impairs the growth of highly divergent retroviruses in human and other primate cells and fully accounts for many previously described antiretroviral activities.

引用

页码：778 / 780

页数：4

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