Genetic Testing in the Diagnosis and Biology of Acute Leukemia 2017 Society for Hematopathology/European Association for Haematopathology Workshop Report

被引：19

作者：

Harris, Marian H. ^{[1
]}

Czuchlewski, David R. ^{[2
]}

Arber, Daniel A. ^{[3
]}

Czader, Magdalena ^{[4
]}

机构：

[1] Boston Childrens Hosp, Dept Pathol, Boston, MA 02115 USA

[2] Univ New Mexico, Hlth Sci Ctr, Dept Pathol, Albuquerque, NM 87131 USA

[3] Univ Chicago, Dept Pathol, 5841 S Maryland Ave, Chicago, IL 60637 USA

[4] Indiana Univ, Dept Pathol & Lab Med, Indianapolis, IN 46204 USA

来源：

AMERICAN JOURNAL OF CLINICAL PATHOLOGY | 2019年 / 152卷 / 03期

关键词：

Hematopathology; Genetics; Molecular diagnostics; ACUTE MYELOID-LEUKEMIA; ACUTE LYMPHOBLASTIC-LEUKEMIA; CHRONIC MYELOGENOUS LEUKEMIA; MINIMAL RESIDUAL DISEASE; MASTERMIND-LIKE; MUTATIONS; IDENTIFICATION; EXPRESSION; AML; RUNX1;

D O I：

10.1093/ajcp/aqz093

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Objectives: The 2017 Workshop of the Society for Hematopathology/European Association for Haematopathology examined the role of molecular genetics in the diagnosis and biology of acute leukemia. Methods: Acute leukemias were reviewed in two sessions: "Genetic Testing in Diagnosis of Acute Leukemias" (53 cases) and "Genetics Revealing the Biology of Acute Leukemias" (41 cases). Results: Cases included acute lymphoblastic leukemia, acute myeloid leukemia, and acute leukemia of ambiguous lineage. Many cases demonstrated genetic alterations of known diagnostic, prognostic, and/or therapeutic significance, while others exhibited alterations that illuminated disease biology. The workshop highlighted the complexity of acute leukemia diagnosis and follow-up, while illustrating advantages and pitfalls of molecular genetic testing. Conclusions: Our understanding of the molecular genetics of acute leukemias continues to grow rapidly. Awareness of the potential complexity of genetic architecture and environment is critical and emphasizes the importance of integrating clinical information with morphologic, immunophenotypic, and molecular genetic evaluation.

引用

页码：322 / 346

页数：25

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