No association between immunohistochemical expression of p53, c-erbB-2, Ki-67, estrogen and progesterone receptors in female papillary thyroid cancer and ionizing radiation

被引：5
|
作者：
Karlsson, MG
Hardell, L
Hallquist, A
机构：
[1] OREBRO MED CTR HOSP,DEPT ONCOL,S-70185 OREBRO,SWEDEN
[2] OREBRO MED CTR HOSP,DEPT PATHOL,S-70185 OREBRO,SWEDEN
[3] STOCKHOLMS SJUKHEM,S-11235 STOCKHOLM,SWEDEN
来源：
CANCER LETTERS | 1997年 / 120卷 / 02期
关键词：
p53; c-erbB-2; Ki-67; estrogen receptors; progesterone receptors; papillary thyroid cancer; ionizing radiation;
D O I：
10.1016/S0304-3835(97)00307-8
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
An association has previously been reported between exposure to medical diagnostic ionizing radiation and papillary thyroid cancer in women. To further evaluate potential mechanisms in carcinogenesis, the expression of p53, c-erbB-2, as well as Ki-67, estrogen and progesterone receptors were analyzed by immunohistochemistry in 19 women exposed to X-rays and for comparison in nine women without such reported exposure. They all had papillary thyroid cancer. No difference was found between these groups. The results of this study showed that p53, c-erbB-2, Ki-67, estrogen and progesterone receptors are not involved in papillary thyroid cancer associated with exposure to medical diagnostic ionizing radiation. (C) 1997 Elsevier Science Ireland Ltd.
引用
收藏
页码：173 / 177
页数：5
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