Dependence Receptors and Cancer: Addiction to Trophic Ligands

被引:56
作者
Gibert, Benjamin [1 ]
Mehlen, Patrick [1 ]
机构
[1] Univ Lyon, Ctr Leon Berard,CNRS,UMR5286, Apoptosis Canc & Dev Lab Equipe Labellisee La Lig, LabEx DEVweCAN,Ctr Cancerol Lyon,INSERM,U1052, Lyon, France
关键词
TRIGGERS APOPTOSIS; TUMOR PROGRESSION; NETRIN-1; UNC5C; DCC; METASTASIS; INHIBITION; EXPRESSION; GUIDANCE;
D O I
10.1158/0008-5472.CAN-14-3652
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Data accumulating over the last 20 years support the notion that some transmembrane receptors are activated not only by their respective ligands but also, differentially, by the withdrawal or absence of these same ligands. In this latter setting, these receptors actively trigger apoptosis. They have been dubbed dependence receptors because their expression confers a state of ligand dependence for survival on the expressing cells. Twenty of these receptors have been identified to date, and several have been shown to inhibit tumor progression by inducing apoptosis. As a corollary, these receptors, or their transduced death signals, are frequently silenced in cancer cells as a selective mechanism to prevent cell death, allowing invasion and metastasis. Drugs aimed at inducing programmed cell death in neoplastic cells by re-engaging the proapoptotic activity induced by unliganded dependence receptors are in late-stage preclinical tests, poised for clinical evaluation. This approach may offer novel opportunities for patient treatments. In this review, we discuss the implications of dependence receptors in limiting cancer progression and address the therapeutic perspectives brought to light by this paradigm. (C) 2015 AACR.
引用
收藏
页码:5171 / 5175
页数:5
相关论文
共 46 条
[11]   Sonic Hedgehog Promotes Tumor Cell Survival by Inhibiting CDON Pro-Apoptotic Activity [J].
Delloye-Bourgeois, Celine ;
Gibert, Benjamin ;
Rama, Nicolas ;
Delcros, Jean-Guy ;
Gadot, Nicolas ;
Scoazec, Jean-Yves ;
Krauss, Robert ;
Bernet, Agnes ;
Mehlen, Patrick .
PLOS BIOLOGY, 2013, 11 (08)
[12]   A GENETIC MODEL FOR COLORECTAL TUMORIGENESIS [J].
FEARON, ER ;
VOGELSTEIN, B .
CELL, 1990, 61 (05) :759-767
[13]   Netrin-1 expression confers a selective advantage for tumor cell survival in metastatic breast cancer [J].
Fitamant, Julien ;
Guenebeaud, Celine ;
Coissieux, Marie-May ;
Guix, Catherine ;
Trilleux, Isabelle ;
Scoazec, Jean-Yves ;
Bachelot, Thomas ;
Bernet, Agnes ;
Mehlen, Patrick .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2008, 105 (12) :4850-4855
[14]   Patched dependence receptor triggers apoptosis through ubiquitination of caspase-9 [J].
Fombonne, Joanna ;
Bissey, Pierre-Antoine ;
Guix, Catherine ;
Sadoul, Remy ;
Thibert, Chantal ;
Mehlen, Patrick .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (26) :10510-10515
[15]   Netrin-1-mediated axon outgrowth requires deleted in colorectal cancer-dependent MAPK activation [J].
Forcet, C ;
Stein, E ;
Pays, L ;
Corset, R ;
Llambi, F ;
Tessler-Lavigne, M ;
Mehlen, P .
NATURE, 2002, 417 (6887) :443-447
[16]   Dependence receptor TrkC is a putative colon cancer tumor suppressor [J].
Genevois, Anne-Laure ;
Ichim, Gabriel ;
Coissieux, Marie-May ;
Lambert, Marie-Pierre ;
Lavial, Fabrice ;
Goldschneider, David ;
Jarrosson-Wuilleme, Loraine ;
Lepinasse, Florian ;
Gouysse, Geraldine ;
Herceg, Zdenko ;
Scoazec, Jean-Yves ;
Tauszig-Delamasure, Servane ;
Mehlen, Patrick .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (08) :3017-3022
[17]   Regulation by miR181 Family of the Dependence Receptor CDON Tumor Suppressive Activity in Neuroblastoma [J].
Gibert, Benjamin ;
Delloye-Bourgeois, Celine ;
Gattolliat, Charles-Henry ;
Meurette, Olivier ;
Le Guernevel, Solen ;
Fombonne, Joanna ;
Ducarouge, Benjamin ;
Lavial, Fabrice ;
Bouhallier, Frantz ;
Creveaux, Marion ;
Negulescu, Ana Maria ;
Benard, Jean ;
Janoueix-Lerosey, Isabelle ;
Harel-Bellan, Annick ;
Delattre, Olivier ;
Mehlen, Patrick .
JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2014, 106 (11)
[18]   Dependence receptors: a new paradigm in cell signaling and cancer therapy [J].
Goldschneider, D. ;
Mehlen, P. .
ONCOGENE, 2010, 29 (13) :1865-1882
[19]   DAPk protein family and cancer [J].
Gozuacik, Devrim ;
Kimchi, Adi .
AUTOPHAGY, 2006, 2 (02) :74-79
[20]   The Dependence Receptor UNC5H2/B Triggers Apoptosis via PP2A-Mediated Dephosphorylation of DAP Kinase [J].
Guenebeaud, Celine ;
Goldschneider, David ;
Castets, Marie ;
Guix, Catherine ;
Chazot, Guillaume ;
Delloye-Bourgeois, Celine ;
Eisenberg-Lerner, Avital ;
Shohat, Galit ;
Zhang, Mingjie ;
Laudet, Vincent ;
Kimchi, Adi ;
Bernet, Agnes ;
Mehlen, Patrick .
MOLECULAR CELL, 2010, 40 (06) :863-876