The impact of obesity on outcomes after critical illness: a meta-analysis

被引：216

作者：

Hogue, Charles W., Jr. ^{[1
,2
]}

Stearns, Joshua D. ^{[2
]}

Colantuoni, Elizabeth ^{[2
]}

Robinson, Karen A.

Stierer, Tracey ^{[2
]}

Mitter, Nanhi ^{[2
]}

Pronovost, Peter J. ^{[2
]}

Needham, Dale M. ^{[3
,4
]}

机构：

[1] Johns Hopkins Univ Hosp, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21287 USA

[2] Johns Hopkins Med Inst, Dept Anesthesiol & Crit Care Med, Baltimore, MD 21205 USA

[3] Johns Hopkins Med Inst, Dept Med, Div Pulm & Crit Care Med, Baltimore, MD 21205 USA

[4] Johns Hopkins Med Inst, Dept Phys Med & Rehabil, Baltimore, MD 21205 USA

来源：

INTENSIVE CARE MEDICINE | 2009年 / 35卷 / 07期

关键词：

Intensive care; Critical illness; Mortality; Body weight; Meta-analysis; BODY-MASS INDEX; RESPIRATORY-DISTRESS-SYNDROME; ACUTE LUNG INJURY; QUALITY-OF-LIFE; INTENSIVE-CARE; MORBID-OBESITY; RISK-FACTORS; MORTALITY; HEALTH; OVERWEIGHT;

D O I：

10.1007/s00134-009-1424-5

中图分类号：

R4 [临床医学];

学科分类号：

1002 ; 100602 ;

摘要：

To assess whether obesity is associated with mortality or other adverse intensive care unit (ICU) and post-ICU outcomes. A meta-analysis of studies from PubMed and EMBASE databases. Twenty-two studies (n = 88,051 patients) were included. Pooled analysis demonstrated no difference in ICU mortality, but lower hospital mortality for obese and morbidly obese subjects (RR 0.76; 95% CI 0.59, 0.92; RR 0.83; 95% CI 0.66, 1.04, respectively) versus normal weight subjects. There was no association between obesity and duration of mechanical ventilation or ICU stay. Morbidly obese versus normal weight patients had longer hospitalizations. No study reported physical function, mental health, or quality of life outcomes after discharge. Obesity is not associated with increased risk for ICU mortality, but may be associated with lower hospital mortality. There is a critical lack of research on how obesity may affect complications of critical illness and patient long-term outcomes.

引用

页码：1152 / 1170

页数：19

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