Quercetin suppresses glomerulosclerosis and TGF-β signaling in a rat model

被引：17
作者：
Liu, Yifan [1 ]
Dai, Enlai [1 ]
Yang, Jing [2 ]
机构：
[1] Gansu Univ Chinese Med, Cooperat Chinese & Western Med Dept, 10 East Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 2, Dept Children Glomerular Dis, Lanzhou 730000, Gansu, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2019年 / 19卷 / 06期
基金：
中国国家自然科学基金;
关键词：
quercetin; glomerulosclerosis; transforming growth factor-beta signaling pathway; ADRIAMYCIN-INDUCED GLOMERULOSCLEROSIS; PODOCYTE; EXPRESSION; INJURY; SUPPLEMENTATION; PROTECTS; PROGRESSION; ACTIVATION; APOPTOSIS; PATHWAYS;
D O I：
10.3892/mmr.2019.10118
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The transforming growth factor-beta (TGF-beta) signaling pathway is an important regulatory pathway in renal fibrosis and is abnormally activated in glomerulosclerosis. Quercetin is a common Chinese herbal medicine and has been reported to inhibit TGF-beta signaling pathway activation. In the present study a glomerulosclerosis rat model was constructed and mice were treated with different concentrations of quercetin. Biochemical parameters, pathological indices and expression levels of TGF-beta signaling pathway-associated proteins were detected using immunohistochemistry and western blotting. It was demonstrated that quercetin significantly improved physiological indices and altered the expression levels of TGF-beta signaling pathway-associated proteins in rats with glomerulosclerosis. In conclusion, quercetin can regulate the TGF-beta signaling pathway and reduce the progression of glomerulosclerosis.
引用
收藏
页码：4589 / 4596
页数：8
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