Quercetin suppresses glomerulosclerosis and TGF-β signaling in a rat model

被引：17
作者：
Liu, Yifan [1 ]
Dai, Enlai [1 ]
Yang, Jing [2 ]
机构：
[1] Gansu Univ Chinese Med, Cooperat Chinese & Western Med Dept, 10 East Dingxi Rd, Lanzhou 730000, Gansu, Peoples R China
[2] Lanzhou Univ, Hosp 2, Dept Children Glomerular Dis, Lanzhou 730000, Gansu, Peoples R China
来源：
MOLECULAR MEDICINE REPORTS | 2019年 / 19卷 / 06期
基金：
中国国家自然科学基金;
关键词：
quercetin; glomerulosclerosis; transforming growth factor-beta signaling pathway; ADRIAMYCIN-INDUCED GLOMERULOSCLEROSIS; PODOCYTE; EXPRESSION; INJURY; SUPPLEMENTATION; PROTECTS; PROGRESSION; ACTIVATION; APOPTOSIS; PATHWAYS;
D O I：
10.3892/mmr.2019.10118
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
The transforming growth factor-beta (TGF-beta) signaling pathway is an important regulatory pathway in renal fibrosis and is abnormally activated in glomerulosclerosis. Quercetin is a common Chinese herbal medicine and has been reported to inhibit TGF-beta signaling pathway activation. In the present study a glomerulosclerosis rat model was constructed and mice were treated with different concentrations of quercetin. Biochemical parameters, pathological indices and expression levels of TGF-beta signaling pathway-associated proteins were detected using immunohistochemistry and western blotting. It was demonstrated that quercetin significantly improved physiological indices and altered the expression levels of TGF-beta signaling pathway-associated proteins in rats with glomerulosclerosis. In conclusion, quercetin can regulate the TGF-beta signaling pathway and reduce the progression of glomerulosclerosis.
引用
收藏
页码：4589 / 4596
页数：8
相关论文
共 49 条
[1]   Nicotinic acid prevents experimental liver fibrosis by attenuating the prooxidant process [J].
Arauz, Jonathan ;
Rivera-Espinoza, Yadira ;
Shibayama, Mineko ;
Favari, Liliana ;
Elena Flores-Beltran, Rosa ;
Muriel, Pablo .
INTERNATIONAL IMMUNOPHARMACOLOGY, 2015, 28 (01) :244-251
[2]   Quercetin modulates Wnt signaling components in prostate cancer cell line by inhibiting cell viability, migration, and metastases [J].
Baruah, Meghna M. ;
Khandwekar, Anand P. ;
Sharma, Neeti .
TUMOR BIOLOGY, 2016, 37 (10) :14025-14034
[3]   ADRIAMYCIN INDUCED GLOMERULOSCLEROSIS IN THE RAT [J].
BERTANI, T ;
ROCCHI, G ;
SACCHI, G ;
MECCA, G ;
REMUZZI, G .
AMERICAN JOURNAL OF KIDNEY DISEASES, 1986, 7 (01) :12-19
[4]   Transforming Growth Factor β Integrates Smad 3 to Mechanistic Target of Rapamycin Complexes to Arrest Deptor Abundance for Glomerular Mesangial Cell Hypertrophy [J].
Das, Falguni ;
Ghosh-Choudhury, Nandini ;
Bera, Amit ;
Dey, Nirmalya ;
Abboud, Hanna E. ;
Kasinath, Balakuntalam S. ;
Choudhury, Goutam Ghosh .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 288 (11) :7756-7768
[5]   TGF-β Tumor Suppression through a Lethal EMT [J].
David, Charles J. ;
Huang, Yun-Han ;
Chen, Mo ;
Su, Jie ;
Zou, Yilong ;
Bardeesy, Nabeel ;
Iacobuzio-Donahue, Christine A. ;
Massague, Joan .
CELL, 2016, 164 (05) :1015-1030
[6]   Regulation of Autophagy by TGF-β: Emerging Role in Kidney Fibrosis [J].
Ding, Yan ;
Choi, Maly E. .
SEMINARS IN NEPHROLOGY, 2014, 34 (01) :62-71
[7]  
Fukuda A, 2017, NEPHROL DIAL TRANSPL, V32, P1818, DOI [10.1093/ndt/gfx060, 10.1093/ndt/gfx047]
[8]   Loss of TGFβ signaling destabilize homeostasis and promotes squalemous cell carcinomas in stratified epithelia [J].
Guasch, Geraldine ;
Schober, Markus ;
Pasolli, H. Amalia ;
Conn, Emily Belmont ;
Polak, Lisa ;
Fuchs, Elaine .
CANCER CELL, 2007, 12 (04) :313-327
[9]   Quercetin supplementation and upper respiratory tract infection: A randomized community clinical trial [J].
Heinz, Serena A. ;
Henson, Dru A. ;
Austin, Melanie D. ;
Jin, Fuxia ;
Nieman, David C. .
PHARMACOLOGICAL RESEARCH, 2010, 62 (03) :237-242
[10]   Regulation of EMT by TGFβ in cancer [J].
Heldin, Carl-Henrik ;
Vanlandewijck, Michael ;
Moustakas, Aristidis .
FEBS LETTERS, 2012, 586 (14) :1959-1970
12345