Oxidative cyclizations: The asymmetric synthesis of (-)-allialcol A

被引：87

作者：

Mihelcic, J ^{[1
]}

Moeller, KD ^{[1
]}

机构：

[1] Washington Univ, Dept Chem, St Louis, MO 63130 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2004年 / 126卷 / 29期

关键词：

D O I：

10.1021/ja048085h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A tandem anodic coupling-Friedel-Crafts alkylation strategy has been used to rapidly complete the asymmetric synthesis of alliacol A. The anodic oxidation reaction allowed for the generation of a new bond between two nucleophiles. In the synthesis, the absolute stereochemistry of the final natural product is set relative to a methyl group that is incorporated early in the sequence using an asymmetric Michael reaction.

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页码：9106 / 9111

页数：6

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