Applications of Genomics in Melanoma Oncogene Discovery

被引：26

作者：

Berger, Michael F. ^{[2
]}

Garraway, Levi A. ^{[1
,2
,3
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[2] Broad Inst MIT & Harvard, Cambridge Ctr 7, Cambridge, MA 02142 USA

[3] Dana Farber Canc Inst, Ctr Canc Genome Discovery, Boston, MA 02115 USA

来源：

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA | 2009年 / 23卷 / 03期

关键词：

Melanoma; Oncogene; DNA sequencing; Microarrays; Gene amplification; Targeted therapy; CUTANEOUS MALIGNANT-MELANOMA; BLADDER-CARCINOMA ONCOGENE; N-RAS MUTATIONS; HUMAN CANCER; IMATINIB MESYLATE; METASTATIC MELANOMA; TRANSFORMING GENES; BRAF MUTATIONS; LUNG-CANCER; COPY NUMBER;

D O I：

10.1016/j.hoc.2009.03.005

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The identification of recurrent alterations in the melanoma genome has provided key insights into the biology of melanoma genesis and progression. These discoveries have come about as a result of the systematic deployment and integration of diverse genomic technologies, including DNA sequencing, chromosomal copy number analysis, and gene expression profiling. Here, the discoveries of several key melanoma oncogenes affecting critical cell pathways are described and the role played by evolving genomics technologies in melanoma oncogene discovery is examined. These advances are being exploited to improve prognosis and treatment of melanoma patients through the development of genome-based diagnostic and targeted therapeutic avenues.

引用

页码：397 / +

页数：19

共 50 条

[31] Epha2 is a critical oncogene in melanoma [J].

Udayakumar, D. ;

Zhang, G. ;

Ji, Z. ;

Njauw, C-N ;

Mroz, P. ;

Tsao, H. .

ONCOGENE, 2011, 30 (50) :4921-4929

[32] Biomarkers Discovery in Medical Genomics Data [J].

Benis, A. ;

Courtine, M. .

SOFTWARE TOOLS AND ALGORITHMS FOR BIOLOGICAL SYSTEMS, 2011, 696 :327-334

[33] Integrative genomics identifies LMO1 as a neuroblastoma oncogene [J].

Wang, Kai ;

Diskin, Sharon J. ;

Zhang, Haitao ;

Attiyeh, Edward F. ;

Winter, Cynthia ;

Hou, Cuiping ;

Schnepp, Robert W. ;

Diamond, Maura ;

Bosse, Kristopher ;

Mayes, Patrick A. ;

Glessner, Joseph ;

Kim, Cecilia ;

Frackelton, Edward ;

Garris, Maria ;

Wang, Qun ;

Glaberson, Wendy ;

Chiavacci, Rosetta ;

Nguyen, Le ;

Jagannathan, Jayanti ;

Saeki, Norihisa ;

Sasaki, Hiroki ;

Grant, Struan F. A. ;

Iolascon, Achille ;

Mosse, Yael P. ;

Cole, Kristina A. ;

Li, Hongzhe ;

Devoto, Marcella ;

McGrady, Patrick W. ;

London, Wendy B. ;

Capasso, Mario ;

Rahman, Nazneen ;

Hakonarson, Hakon ;

Maris, John M. .

NATURE, 2011, 469 (7329) :216-220

[34] Dividing and conquering: controlling advanced melanoma by targeting oncogene-defined subsets [J].

Keith T. Flaherty .

Clinical & Experimental Metastasis, 2012, 29 :841-846

[35] Combining immunotherapy with oncogene-targeted therapy: a new road for melanoma treatment [J].

Aris, Mariana ;

Marcela Barrio, Maria .

FRONTIERS IN IMMUNOLOGY, 2015, 6

[36] Using genetics and genomics strategies to personalize therapy for cancer: Focus on melanoma [J].

Nathanson, Katherine L. .

BIOCHEMICAL PHARMACOLOGY, 2010, 80 (05) :755-761

[37] C-myc oncogene expression in human melanoma and its relationship with tumour antigenicity [J].

Grover, R ;

Ross, DA ;

Richman, PI ;

Robinson, B ;

Wilson, GD .

EUROPEAN JOURNAL OF SURGICAL ONCOLOGY, 1996, 22 (04) :342-346

[38] Somatic Hypermutation of the YAP Oncogene in a Human Cutaneous Melanoma [J].

Zhang, Xiaomeng ;

Tang, Jian Zhong ;

Vergara, Ismael A. ;

Zhang, Youfang ;

Szeto, Pacman ;

Yang, Lie ;

Mintoff, Christopher ;

Colebatch, Andrew ;

McIntosh, Lachlan ;

Mitchell, Katrina A. ;

Shaw, Evangeline ;

Rizos, Helen ;

Long, Georgina, V ;

Hayward, Nicholas ;

McArthur, Grant A. ;

Papenfuss, Anthony T. ;

Harvey, Kieran F. ;

Shackleton, Mark .

MOLECULAR CANCER RESEARCH, 2019, 17 (07) :1435-1449

[39] Oncogene status as a diagnostic tool in ocular and cutaneous melanoma [J].

Griewank, Klaus G. ;

Schilling, Bastian ;

Scholz, Simone L. ;

Metz, Claudia H. ;

Livingstone, Elisabeth ;

Sucker, Antje ;

Moeller, Inga ;

Reis, Henning ;

Franklin, Cindy ;

Cosgarea, Ioana ;

Hillen, Uwe ;

Steuhl, Klaus-Peter ;

Schadendorf, Dirk ;

Westekemper, Henrike ;

Zimmer, Lisa .

EUROPEAN JOURNAL OF CANCER, 2016, 57 :112-117

[40] Hypomethylation of the Xmrk oncogene promoter in melanoma cells of Xiphophorus [J].

Altschmied, J ;

Ditzel, L ;

Schartl, M .

BIOLOGICAL CHEMISTRY, 1997, 378 (12) :1457-1466

← 1 2 3 4 5 →