Serum Biomarkers for Traumatic Brain Injury

被引：29
|
作者：
Neher, Miriam D.
Keene, Chesleigh N.
Rich, Megan C.
Moore, Hunter B.
Stahel, Philip F. [1 ]
机构：
[1] Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80204 USA
来源：
SOUTHERN MEDICAL JOURNAL | 2014年 / 107卷 / 04期
关键词：
astroglial injury; axonal injury; biomarkers; neuronal injury; outcome prediction; risk stratification; traumatic brain injury; NEURON-SPECIFIC-ENOLASE; FIBRILLARY ACIDIC PROTEIN; MILD HEAD-INJURY; C-TERMINAL HYDROLASE; MYELIN BASIC-PROTEIN; CEREBROSPINAL-FLUID; BIOCHEMICAL MARKERS; ELEVATED LEVELS; S-100B PROTEIN; INTRACRANIAL LESIONS;
D O I：
10.1097/SMJ.0000000000000086
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
There is a lack of reliable serum biomarkers for routine use in the diagnostic workup of people with traumatic brain injury. Multiple biomediators and biomarkers have been described in the pertinent literature in recent years; however, only a few candidate molecules have been associated with high sensitivity and high specificity for risk stratification and outcome prediction after traumatic brain injury. This review was designed to provide an overview of the state of the art regarding established serum biomarkers in the field and to outline future directions of investigation.
引用
收藏
页码：248 / 255
页数：8
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