Serum Biomarkers for Traumatic Brain Injury

被引：29
|
作者：
Neher, Miriam D.
Keene, Chesleigh N.
Rich, Megan C.
Moore, Hunter B.
Stahel, Philip F. [1 ]
机构：
[1] Univ Colorado, Sch Med, Denver Hlth Med Ctr, Denver, CO 80204 USA
来源：
SOUTHERN MEDICAL JOURNAL | 2014年 / 107卷 / 04期
关键词：
astroglial injury; axonal injury; biomarkers; neuronal injury; outcome prediction; risk stratification; traumatic brain injury; NEURON-SPECIFIC-ENOLASE; FIBRILLARY ACIDIC PROTEIN; MILD HEAD-INJURY; C-TERMINAL HYDROLASE; MYELIN BASIC-PROTEIN; CEREBROSPINAL-FLUID; BIOCHEMICAL MARKERS; ELEVATED LEVELS; S-100B PROTEIN; INTRACRANIAL LESIONS;
D O I：
10.1097/SMJ.0000000000000086
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
There is a lack of reliable serum biomarkers for routine use in the diagnostic workup of people with traumatic brain injury. Multiple biomediators and biomarkers have been described in the pertinent literature in recent years; however, only a few candidate molecules have been associated with high sensitivity and high specificity for risk stratification and outcome prediction after traumatic brain injury. This review was designed to provide an overview of the state of the art regarding established serum biomarkers in the field and to outline future directions of investigation.
引用
收藏
页码：248 / 255
页数：8
相关论文
共 50 条
  • [21] Biomarkers of Neuroinflammation in Traumatic Brain Injury
    Gerber, Kathryn S.
    Alvarez, Gema
    Alamian, Arsham
    Behar-Zusman, Victoria
    Downs, Charles A.
    CLINICAL NURSING RESEARCH, 2022, 31 (07) : 1203 - 1218
  • [22] Inflammatory Biomarkers of Traumatic Brain Injury
    Johnson, Nathan H.
    Hadad, Roey
    Taylor, Ruby Rose
    Rodriguez Pilar, Javier
    Salazar, Osman
    Llompart-Pou, Juan Antonio
    Dietrich, W. Dalton
    Keane, Robert W.
    Perez-Barcena, Jon
    de Rivero Vaccari, Juan Pablo
    PHARMACEUTICALS, 2022, 15 (06)
  • [23] Diagnostic biomarkers in traumatic brain injury
    Wanke-Jellinek, L.
    van Griensven, M.
    Biberthaler, P.
    UNFALLCHIRURG, 2014, 117 (08): : 693 - 698
  • [24] Serum biomarkers identify critically ill traumatic brain injury patients for MRI
    Sophie Richter
    Stefan Winzeck
    Endre Czeiter
    Krisztina Amrein
    Evgenios N. Kornaropoulos
    Jan Verheyden
    Gabriela Sugar
    Zhihui Yang
    Kevin Wang
    Andrew I. R. Maas
    Ewout Steyerberg
    András Büki
    Virginia F. J. Newcombe
    David K. Menon
    Critical Care, 26
  • [25] SERUM MICRORNAS AS SPECIFIC BIOMARKERS OF SEVERE TO MILD HUMAN TRAUMATIC BRAIN INJURY
    Bhomia, Manish
    Balakathiresan, Nagaraja
    Wang, Kevin
    Papa, Linda
    Maheshwari, Radha
    JOURNAL OF NEUROTRAUMA, 2016, 33 (13) : A19 - A19
  • [26] BIOMARKERS IN SERUM AFTER EXPERIMENTAL DIFFUSE AND FOCAL TRAUMATIC BRAIN INJURY IN RATS
    Rostami, Elham
    Gyorgy, Andrea
    Davidsson, Johan
    Walker, John
    Wingo, Dan
    Angeria, Maria
    Bellander, Bo-Michael
    Agoston, Denes
    Risling, Marten
    JOURNAL OF NEUROTRAUMA, 2011, 28 (05) : A11 - A11
  • [27] LIPIDOMIC PROFILING OF SERUM FOR THE DEVELOPMENT OF BLOOD BASED BIOMARKERS FOR TRAUMATIC BRAIN INJURY
    Hogan, S.
    Jones, C. M.
    Gaul, D. A.
    Zhou, M.
    Rooney, B. A.
    Fernandez, F.
    LaPlaca, M. C.
    JOURNAL OF NEUROTRAUMA, 2014, 31 (12) : A42 - A42
  • [28] Serum biomarkers identify critically ill traumatic brain injury patients for MRI
    Richter, Sophie
    Winzeck, Stefan
    Czeiter, Endre
    Amrein, Krisztina
    Kornaropoulos, Evgenios N.
    Verheyden, Jan
    Sugar, Gabriela
    Yang, Zhihui
    Wang, Kevin
    Maas, Andrew I. R.
    Steyerberg, Ewout
    Buki, Andras
    Newcombe, Virginia F. J.
    Menon, David K.
    CRITICAL CARE, 2022, 26 (01)
  • [29] Serum biomarkers as predictor of long term outcome in severe traumatic brain injury
    Raheja, Amol
    Sinha, Sumit
    Samson, Neha
    Bhoi, Sanjeev
    Selvi, Arul
    Sharma, Pushpa
    Sharma, Bhawani
    JOURNAL OF NEUROSURGERY, 2016, 124 (04) : A1186 - A1187
  • [30] Serum biomarkers in severe paediatric traumatic brain injury-a narrative review
    Ganeshalingham, Anusha
    Beca, John
    TRANSLATIONAL PEDIATRICS, 2021, 10 (10) : 2720 - 2737
12345