YM-215343, a novel antifungal compound from Phoma sp QN04621

被引：31

作者：

Shibazaki, M

Taniguchi, M

Yokoi, T

Nagai, K

Watanabe, M

Suzuki, K

Yamamoto, T

机构：

[1] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Microbiol Lab, Itabashi Ku, Tokyo 1748511, Japan

[2] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Leed Discovery Labs, Itabashi Ku, Tokyo 1748511, Japan

[3] Yamanouchi Pharmaceut Co Ltd, Inst Drug Discovery Res, Anal & Metab Labs, Tsukuba, Ibaraki 3058585, Japan

[4] Chiba Univ, Grad Sch Pharmaceut Sci, Dept Microbiol & Mol Genet, Chiba 2638522, Japan

来源：

JOURNAL OF ANTIBIOTICS | 2004年 / 57卷 / 06期

关键词：

D O I：

10.7164/antibiotics.57.379

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Through our screening for novel antifungal compounds, YM-215343 was found in the culture extract of Phoma sp. QN04621. The structure of YM-215343 was determined by several spectroscopic experiments as a novel compound closely related to apiosporamide and fischerin. YM-215343 exhibited antifungal activity against the pathogenic fungi, Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus with MIC values of 2similar to16 mug/ml. It also showed cytotoxicity against HeLa S3 cells with an IC50 of 3.4 mug/ml.

引用

页码：379 / 382

页数：4

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