Effects of dorsolateral prefrontal cortex lesion on motor habit and performance assessed with manual grasping and control of force in macaque monkeys

被引：13

作者：

Badoud, S. ^{[1
]}

Borgognon, S. ^{[1
]}

Cottet, J. ^{[1
]}

Chatagny, P. ^{[1
]}

Moret, V. ^{[1
]}

Fregosi, M. ^{[1
]}

Kaeser, M. ^{[1
]}

Fortis, E. ^{[1
]}

Schmidlin, E. ^{[1
]}

Bloch, J. ^{[2
]}

Brunet, J. F. ^{[2
]}

Rouiller, E. M. ^{[1
]}

机构：

[1] Univ Fribourg, Lab Sensorimotor & Multisensory Integrat, Fribourg Cognit Ctr, Res Cluster Neurosci,Dept Med, Chemin Musee 5, CH-1700 Fribourg, Switzerland

[2] Lausanne Univ Hosp CHUV, Dept Neurosurg, Lausanne, Switzerland

来源：

BRAIN STRUCTURE & FUNCTION | 2017年 / 222卷 / 03期

基金：

瑞士国家科学基金会;

关键词：

Dorsolateral prefrontal cortex (dlPFC); Manual dexterity; Grip force control; Motor habits; Precision grip; BRAIN-CELL AUTOTRANSPLANTATION; DIRECTED MOVEMENT SEQUENCE; PRECISION GRIP; FRONTAL-CORTEX; BASAL GANGLIA; ADULT MONKEYS; AREAS; FMRI; SUPPLEMENTARY; DEXTERITY;

D O I：

10.1007/s00429-016-1268-z

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

In the context of an autologous adult neural cell ecosystem (ANCE) transplantation study, four intact adult female macaque monkeys underwent a unilateral biopsy of the dorsolateral prefrontal cortex (dlPFC) to provide the cellular material needed to obtain the ANCE. Monkeys were previously trained to perform quantitative motor (manual dexterity) tasks, namely, the "modified-Brinkman board" task and the "reach and grasp drawer" task. The aim of the present study was to extend preliminary data on the role of the prefrontal cortex in motor habit and test the hypothesis that dlPFC contributes to predict the grip force required when a precise level of force to be generated is known beforehand. As expected for a small dlPFC biopsy, neither the motor performance (score) nor the spatiotemporal motor sequences were affected in the "modified-Brinkman board" task, whereas significant changes (mainly decreases) in the maximal grip force (force applied on the drawer knob) were observed in the "reach and grasp drawer" task. The present data in the macaque monkey related to the prediction of grip force are well in line with the previous fMRI data reported for human subjects. Moreover, the ANCE transplantation strategy (in the case of stroke or Parkinson's disease) based on biopsy in dlPFC does not generate unwanted motor consequences, at least as far as motor habit and motor performance are concerned in the context of a sequential grasping a small objects, which does not require the development of significant force levels.

引用

页码：1193 / 1206

页数：14