Two new flavones glycosides with antimicrobial activities from Clerodendrum formicarum Gurke (Lamiaceae)

被引:7
作者
Mahamat, Achi [1 ]
Gbaweng, Abel Joel Yaya [2 ]
Fotsing, Maurice Tagatsing [1 ]
Talla, Emmanuel [3 ]
Fekam, Fabrice Boyom [4 ]
Henoumont, Celine [5 ]
Sophie, Laurent [5 ]
Mbafor, Joseph Tanyi [1 ]
机构
[1] Univ Yaounde I, Dept Organ Chem, Fac Sci, Yaounde, Cameroon
[2] Inst Med Res & Med Plants Studies, Ctr Res Med Plants & Tradit Med, Yaounde, Cameroon
[3] Univ Ngaoundere, Dept Chem, Fac Sci, POB 454, Ngaoundere, Cameroon
[4] Univ Yaounde I, Dept Biochem, Fac Sci, Yaounde, Cameroon
[5] Univ Mons, Dept Gen Organ Chem & Biomed, Lab NMR & Mol Imaging, Mons, Belgium
关键词
Clerodendrum formicarum; Lamiaceae; flavone; antimicrobial; GRAM-NEGATIVE BACILLI; INFECTIONS;
D O I
10.1080/14786419.2019.1613397
中图分类号
O69 [应用化学];
学科分类号
081704 ;
摘要
Clerodendrum formicarum Gurke from the Lamiaceae family is a Cameroonian medicinal plant. The crude methanol, methanol residual and ethyl acetate extracts of leaves have been phytochemically studied using chromatography column to afford four compounds; two new flavones glycoside: clerodendronone 1a (3) and clerodendronone 1b (4) along with two known compounds: 5,7-dihydroxy-4 '-methoxyflavone (1) and 5-hydroxy-7,4 '-dimethoxyflavone (2). Compound structures have been elucidated on the basis of their spectroscopy data and with literature information. The anti-microbial activities of extracts and three isolated compounds were performed. The antibacterial activity was evaluated against four gram positive, five gram negative and three fungus. Clerodendronone 1b (4) showed good antibacterial activity against bacterial gram negative Shigella flexineri NR518 (MIC = 62.5 mu g/ml) and moderate activity against Staphylococcus aureus NR46374 (MIC = 250 mu/ml). The ethyl acetate extract recorded good antibacterial activity against Staphylococcus aureus NR46003 (MIC = 125 mu g/ml) and Staphylococcus aureus NR46374 (MIC = 125 mu g/ml).
引用
收藏
页码:951 / 959
页数:9
相关论文
共 29 条
[1]   Two new aromatic acids from Clerodendrum formicarum Gurke (Lamiaceae) of Cameroon [J].
Ali, Muhammad Shaiq ;
Ahmed, Zeeshan ;
Ali, Muhammad Imran ;
Ngoupayo, Joseph .
JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH, 2010, 12 (10) :894-898
[2]   Terpenoids from Clerodendrum formicarum Gurke (Lamiaceae) of Cameroon [J].
Ali, Muhammad Shaiq ;
Ahmed, Zeeshan ;
Ngoupayo, Joseph ;
Ali, Muhammad Imran .
ZEITSCHRIFT FUR NATURFORSCHUNG SECTION B-A JOURNAL OF CHEMICAL SCIENCES, 2010, 65 (04) :521-524
[3]  
[Anonymous], 1996, WATER SANITATION FAC, P112
[4]  
[Anonymous], 2008, M27A3 CLSI
[5]   Clerodendrumol, A New Triterpenoid from Clerodendrum yaundense Gurke (Lamiaceae) [J].
Awouafack, Maurice D. ;
Aimaiti, Simayijiang ;
Tane, Pierre ;
Morita, Hiroyuki .
HELVETICA CHIMICA ACTA, 2016, 99 (02) :161-164
[6]   Influence of matching for exposure time on estimates of attributable mortality caused by nosocomial bacteremia in critically ill patients [J].
Blot, S ;
De Bacquer, D ;
Hoste, E ;
Depuydt, P ;
Vandewoude, K ;
De Waele, J ;
Benoit, D ;
De Schuijmer, J ;
Colardyn, F ;
Vogelaers, D .
INFECTION CONTROL AND HOSPITAL EPIDEMIOLOGY, 2005, 26 (04) :352-356
[7]   A European perspective on nosocomial urinary tract infections II.: Report on incidence, clinical characteristics and outcome (ESGNI-004 study) [J].
Bouza, E ;
San Juan, R ;
Muñoz, P ;
Voss, A ;
Kluytmans, J .
CLINICAL MICROBIOLOGY AND INFECTION, 2001, 7 (10) :532-542
[8]  
Chaturvedi GN, 1983, ANCIENT SCI LIFE, V3, P216
[9]  
Clinical Laboratory Standard Institute (CLSI), 2008, REF METH DIL ANT SUS
[10]  
Delahaye C., 2009, Journal of Medical and Biological Sciences, V3, P1